차의과학대학교
 
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나영화

나영화 교수

전공의약화학, 의약품 합성
연락처 031-881-7164 yna7315@cha.ac.kr

학력

  • 1985-1989 : 영남대학교 약학대학, 학사
  • 1989-1991 : 영남대학교 약학과, 석사
  • 1996-2000 : University of Houston, Ph. D.
  • 2001-2002 : University of Arizona, Post Doc.

경력

  • 2004.09.-2011.01: 대구가톨릭대학교 약학대학
  • 2011.02.-현재: 차 의과학대학교 약학대학
  • 2011.09. – 2014.02: 종합약학연구소 소장
  • 2014.03. – 2016.02: 약학과 및 대학원 학과장


    • 연구실 소개

    본 연구실은 새로운 신약후보 물질 발굴을 위하여 유기합성과 약물학적 활성 연구를 이용하여 다양한 구조의 합성 또는 천연물 유래 생리활성 화합물들의 전합성 또는 구조 변경 및 최적화 연구를 수행하고 있다.

    연구분야로는 topoisomerase와 PKCK2효소 기능을 억제하여 항암효과를 가지는 유도체들을 합성을 통하여 연구개발하고 있으며, 약물학적 활성 및 작용기전을 공동 연구진들과 함께 수행하고 있다. 또한 천연에서 유래하는 licochalcone E 및 chalcone 화합물의 약물학적 활성 연구 결과를 바탕으로 구조변환 작업을 수행하여 새로운 항염증, 항산화 및 항치매 효능을 가지는 신약후보물질 도출을 위한 연구를 수행하고 있다.

    이외에도 피부미백제, 위장관 기능조절제, 항당뇨 기능등의 생리활성 후보 물질들을 발굴하고 새로운 신약후보물질로 개발하기 위한 의약화학적 연구를 수행하고 있다.



    특허 (국내)
  • 항암제 조성물 (2016) 등록번호: 10-1615009, 등록일자: 2016. 04. 18
  • 신규한 칼콘 유도체 및 이의 용도 (2013) 출원번호 10-2013-0071218. 출원일자 2013. 06. 20
  • PCAF 저해제를 유효성분으로 함유하는 퇴행성 뇌질환의 예방 및 치료용 조성물 (2014) 출원번호 10-2014-013465. 출원일자 2014. 09. 29
  • 신규한 항암제 보조용 화합물, 이의 제조방법 및 이를 포함하는 항암제 보조용 조성물 (2013), 등록번호: 10-1326900-0000, 등록일자: 2013.11.01
  • 갈릭산 유도체를 유효성분으로 함유하는 항암 조성물, 대한민국 (2013), 등록번호: 10-1286153-0000, 등록일자: 2013.07.09
  • 신규한 화합물, 이의 제조방법 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물, 대한민국 (2013), 등록번호: 10-1281955-0000, 등록일자: 2013.06.27
  • 토포아이소머라제 (ｔｏｐｏｉｓｏｍｅｒａｓｅ) Ⅰ및 Ⅱ 활성 억제제로 유용한 신규한 2,4-디페닐-6-아릴 피리딘 계 화합물, 이의 제조방법 및 이를 포함하는 조성물, 대한민국, (2012) 등록번호: 10-1182058-0000
  • 리코칼콘계 화합물의 제조방법, 대한민국 (2010), 등록번호: 10-0963899-0000

    • 특허 (국제)
  • ANTICANCER-AIDING COMPOUND, METHOD FOR PREPARING THE SAME, ANTICANCER-AIDING COMPOSITION CONTAINING THE SAME AND METHOD FOR REDUCING ANTICANCER DRUG RESISTANCE USING THE SAME; US patent (2014), Patent No. US 8,846,749 B2. 등록일자: 2014. 09. 30.

논문

    주요연구내용
  • Melanin 생합성 저해기능의 피부미백제 개발
  • Topoisomerase를 타겟으로 한 항암제 개발
  • CK2 저해제 개발
  • Chalcone 유도체 합성과 생리활성 연구


    • [최근5년간 논문]
  • Kyung-Hwa Jeon, Eunyoung Lee, Kyu-Yeon Jun, Ji-Eun Eom, Soo Yeon Kwak, Younghwa Na, Youngjoo Kwon Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against -calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation Eur. J. Med. Chem. 2016, Accepted. (20160608).
  • Soo-Yeon Park, Younghwa Na, Mee-Hee Lee, Jae-Sung Seo, Yoo-Hyun Lee, Kyung-Chul Choi, Hyo-Kyoung Choi, Ho-Geun Yoon SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth Oncotarget, 2016 (20160426)
  • Kyung Hye Baek, Han Vit Yu, Eosu Kim, Younghwa Na, Youngjoo Kwon Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway Oncotarget, 2016 , 21 (7) 30831-30844(20160418)
  • Radha Karki, Kyu-Yeon Jun, Tara Man Kadayat, Somin Shin, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee, A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study Eur. J. Med. Chem. 2016, 113, 228-245. (20160504).
  • Pritam Thapa, Tara Man Kadayat, Seojeong Park, Somin Shin, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents Bioorg. Chem. 2016, 66, 145-159.
  • Tara Man Kadayat, Seojeong Park, Kyu-Yeon Jun, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee. Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines Bioorg. Med. Chem. 2016, 26(7), 1726-1731. (20160401)
  • Eun-Jung Bak, Kyung-Chul Choi, Sungil Jang, Gye-Hyeong Woo, Ho-Geun Yoon, Younghwa Na, Yun-Jung Yoo, Youngseok Lee, Yangsik Jeong, Jeong-Heon Cha, Licochalcone F alleviates glucose tolerance and chronic inflammation in diet-induced obese mice through Akt and p38 MAPK, Clinical Nutrition, 2016, 35(2), 414-421.(20160401)
  • Tara Man Kadayat, Chanju Song, Somin Shin, Til Bahadur, Thapa Magar, Ganesh Bist, Aarajana Shrestha, Pritam Thapa, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of 2-phenyl- or hydroxylated 2- phenyl-4-aryl-5H-indeno[1,2-b]pyridines Bioorg. Med. Chem. 2015, 23(13), 3499-3512. (20150701)
  • Radha Karki,, Chanju Song,] Tara Man Kadayat, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee Topoisomerase I and II inhibitory activity, cytotoxicity, andtructure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines, Bioorg. Med. Chem. 2015, 23(13), 3638-3654. (20150701)
  • Kwon, Han Byeol; Park, Chanmi; Jeon, Kyung-Hwa; Lee, Eunyoung; Park, So-Eun; Jun, Kyu-Yeon; Kadayat, Tara Man; Thapa, Pritam; Karki, Radha; Na, Younghwa; Park, Mi Sun; Rho, Seung Bae; Lee, Eung-Seok; Kwon, Youngjoo A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases. J. Med. Chem. 2015, 58 (3), 1100–1122.
  • Song Wha Chae, Sangwook Woo,Jung Hyun Park,Youngjoo Kwon,Younghwa Na, Hwa Jeong Lee Xanthone Analogues as Potent Modulators of Intestinal P-glycoprotein, Eur. J. Med. Chem. 2015, 93, 237-245.
  • Soo-Yeon Park, Mi-Jeong Kim, Young Jun Kim, Yoo-Hyun Lee, Donghyuk Bae, Sunoh Kim, Younghwa Na, Ho-Geun Yoon Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation in Aß-induced Alzheimer’s model. Int. J. Mol. Med. 2015, 35(4), 1109-1118.
  • Cheng-Hao Jin, Kyu-Yeon Jun, Eunjung Lee, Seongrak Kim,, Youngjoo Kwon, Kunhong Kim, Younghwa Na Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor, Bioorg. Med. Chem. 2014, 22 (17), 4553-4565
  • Kyung Hye Baek, Radha Karki, Eung-Seok Lee, Younghwa Na, Youngjoo Kwon Synthesis and Investigation of Dihydroxychalcones as Calpain and Cathepsin Inhibitors, Bioorg. Chem. 2013, 51, 24-30. (Co-corresponding)
  • So-Eun Park, In-Hye Chang, Kyu-Yeon Jun, Eunyoung Lee, Eung-Seok Lee, Younghwa Na, Youngjoo Kwon 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase II catalytic inhibitor with low DNA damage, Eur. J. Med. Chem 2013, 69, 139-145. (Co-corresponding)
  • Jung Min Nam, Kyung-Hwa Jeon, Hanbyeol Kwon, Eunyoung Lee, Kyu-Yeon Jun, Yeung Bae Jin, Yun-Sil Lee, Younghwa Na, Youngjoo Kwon, Dithiiranylmethyloxy azaxanthone shows potent anti-tumor activity via suppression of HER2 expression and HER2-mediated signals in HER2-overexpressing breast cancer cells, European Journal of Pharmaceutical Sciences, 2013, 50(2), 181-190. (Co-corresponding)
  • Seok-Ho Kim, Eunyoung Lee, Kyung Hye Baek, Han Byeol Kwon, Hyunjung Woo, Eung-Seok Lee, Youngjoo Kwon, Younghwa Na. Chalcones, Inhibitors for Topoisomerase I and Cathepsin B and L, as Potential Anti-cancer Agents. Bioorg. Med. Chem. Lett.. 2013, 23, 3320-3324.

저서/역서/편서