고정재

인사말

고정재교수

전문분야 |  생식생리학, 발생학
전화번호 | 031-881-7133
E – mail | highko@cha.ac.kr

주요경력

1985 – 1986 건국대학교 축산대학 축산학과 연구조교
1986 – 1994 차병원 여성의학연구소 연구실장
1995 – 2003 차병원 여성의학연구소 연구부장
2000 – 2001 미국 University of california, Davis 방문교수
2001 – 2004 차 의과학대학교 기획처장
2001 – 2004 차 의과학대학교 기초의학연구소 연구소장
2001 – 2011 (주) 차바이오메드 대표이사
2003 – 2010 차 의과학대학교 연구처장
2004 – 2009 교육부 수도권 대학특성화 지원사업 사업단장
2006 – 현재 산업자원부 지역혁신특성화사업 사업단장
2009 – 현재 교과부지정 대학중점연구소 소장
1997 – 현재 차 의과학대학교 교수
2016 – 현재 차병원그룹 생식의학 연구본부장

주요연구내용

암의 진단을 위한 바이오마커 발굴과 생식세포 연구를 통한 난임치료, 난치병의 치료를 위해 줄기세포에 관한 기초연구와 기능성식품의 응용 가능성에 대해 연구를 진행하고 있으며, 구체적인 연구는 아래와 같다.
– 각종 암관련 바이오 마커의 발굴을 통한 진단용 kit의 개발
– 공여제대혈 이식의 공여자, 수여자 적합성 여부 판정을 위한 유전자 검사(HLA typing)
– 혈전의 기초연구과 기능성 식품을 이용한 임상응용 가능성 연구
– 생식세포관련 기초연구

[최근5년 논문]

▷ Nayeon Lee,Jae Woo Park,Hyung Joon Kim,Ju Hun Yeon,Jihye Kwon,KO JUNG JAE,Oh seung hun,Kim, Hyun Sook,Kim, Aeri,Baek Soo Han,Sang Chul Lee,oo Li Jeon,jihwan Song.Monitoring the Differentiation and Migration Patterns of Neural Cells Derived from Human Embryonic Stem Cells Using a Microfluidic Culture System. Molecules and cells 1016-8478. 2014

▷ 주진영,이종환,고해영,이용승,임도환,김은영,조수정,고정재,이수만,이영식,이경아,김순학.Microinjection free delivery of miRNA inhibitor into zygotes.Sci Rep 2045-2322.2014

▷ Hae Young Ko,이종환,주진영,이용승,Hyejung Heo,KO JUNG JAE,Soonhag Kim.A color-tunable molecular beacon to sense miRNA-9 expression during neurogenesis.Sci Rep 2045-2322. 2014

▷ 나형철,전영주,KO JUNG JAE,im ji hyang,김영란,sun-hee cha,choi Youngsok,이우식,kim, Nam Keun.
Association of inhibin α gene promoter polymorphisms with risk of idiopathic primary ovarian insufficiency in Korean women.Maturitas 0378-5122. 2014

▷ LEE SUYEON,이현서,김은영,KO JUNG JAE,윤태기,이우식,Lee Kyung-Ah.Thioredoxin-interacting protein regulates glucose metabolism and affects cytoplasmic streaming in mouse oocytes.PLoS One 1932-6203. 2014

▷ Won Yun Choi,Hwang Gyun Jeon,oung Chung,Jung Jin Lim,Dong Hyuk Shin,Jung Mo Kim,Byeong Seong Ki,Seung-Hun Song,Seong-Jun Choi,Keun-Hong Park,Sung Han Shim,isook Moon,Sung Jun Jung,Hyun Mi Kang,Seah Park,yung Min Chung,KO JUNG JAE,차광열,유태기,Haekwon Kim,이동률.Isolation and Characterization of Novel, Highly Proliferative Human CD34/CD73-Double-Positive Testis-Derived Stem Cells for Cell Therapy.Stem Cells Dev 1547-3287. 2014

▷ Sunshin Kim,Park Kyung Chae,신철,조남희,KO JUNG JAE,고인성,KyuBum Kwack.Diplotyper: diplotype-based association analysis.BMC Medical Genomics 1755-8794. 2013

▷ 나형철,전영주,Choi Youngsok,Sung Han Shim,고정재,윤태기,sun-hee cha,Kim, Nam Keun.Association between kinase insert domain-containing receptor (KDR) polymorphisms (-604T-C, 1192G-A, 1719A-T) and premature ovarian failure in Korean women. Menopause (New York, N.Y.) 1072-3714. 2012

▷ 조중현,Haengseok Song,Park, Sang Gyu,Soo-Hong, Lee,고정재,박종혁,정재민,전용필,이동률.Regulation of Differentiation Potential of Human Mesenchymal Stem Cells by Intracytoplasmic Delivery of Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Protein Using Cell-Penetrating Peptide (CPP).Stem cells (Dayton, Ohio) 1066-5099. 2012

▷ 나형철,최이슬,전영주,Choi Youngsok,sun-hee cha,최동희,고정재,Sung han Shim, Kim, namkeun.Solute carrier family 19, member 1 (SLC19A1) polymorphisms (-43T-C, 80G-A, 696C-T) and haplotypes in idiopathic recurrent spontaneous abortion in a Korean population. Reproductive sciences (Thousand Oaks, Calif.) 1933-7191. 2012

▷ 편정아,김선신,차동현,고정재,Kyubum Kwack.Epistasis between the HSD17B4 and TG polymorphisms is associated with premature ovarian failure. Fertility and sterility 0015-0282. 2012

▷ Lee Dong Hyeon,KO JUNG JAE,young keon, Jee,Hyung Min Chung,hwang, Tae Sun.Proteomic Identification of RREB1, PDE6B, and CD209 Up-Regulated in Primitive Gut Tube Differentiated From Human Embryonic Stem Cells.Pancreas 0885-3177. 2012

▷ Hanna Yoo,Jung Ki Yoo,Jimin Lee,Dong Ryul Lee,Jung Jae Ko,Oh seung hun,Young Kug Choo,Kim,Jin Kyeoung.The hsa-miR-5787 represses cellular growth by targeting eukaryotic translation initiation factor 5 (eIF5) in fibroblasts.Biochemical and biophysical research communications 0006-291X.2011

▷ Young Joo Jeon,Choi Youngsok,Sung Han Shim,최이슬,Jung Jae Ko,Tae Ki Yoon,sun-hee cha,Kim, Nam Keun.Vascular endothelial growth factor gene polymorphisms in Korean patients with premature ovarian failure.European journal of obstetrics, gynecology, and reproductive biology 0301-2115. 2011

▷ Mira Park,Jiyou Han,Jeong-Jae Ko,Woo-Sik Lee,Tae Ki Yoon,Kangseok Lee,Jeehyeon Bae.Maternal exposure to fenarimol promotes reproductive performance in mouse offspring. Toxicol Lett 0378-4274. 2011

▷ Jae-Hong Kim,Ji-Hyun Yeom,Jeong-Jae Ko,Min Su Han,Kangseok Lee,Kangseok Lee,Jeehyeon Bae.Effective delivery of anti-miRNA oligonucleotides by functionalized gold nanoparticles.Journal of biotechnology 0168-1656. 2011

▷ 김선신,편정아,차동현,고정재,KyuBum Kwack.Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure. Fertility and sterility 0015-0282. 2011

▷ Ho-Oak Park,Jeong-Jae Ko,Jeehyeon Bae.Simazine-induced alteration of the expression levels of apoptosis- and steroidogenesis-regulating genes in testicular cells.발생과 생식 1226-6752. 2011

▷ Ahyoung Kim,Mira Park,Tae Ki Yoon,Woo Sik Lee,Jeong-Jae Ko,Kangseok Lee,Kangseok Lee.Maternal exposure to benzo[b]fluoranthene disturbs reproductive performance in male offspring mice. Toxicol Lett 0378-4274.2011

▷ Chung IH, Lee HC, Park JH, Ko JJ, Lee SH, Chung TG, Kim HJ, Cha KY, Lee S. The biallelic expression pattern of X-linked genes in Klinefelter syndrome by pyrosequencing. Am J Med Genet A 140(5):527-532. 2006

▷ Kim NK, Choi YK, Kang MS, Choi DH, Cha SH, An MO, Lee S, Jeung M, Ko JJ, Oh D. Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine. Thrombosis Research 117(6):653-658. 2006

▷ Lee K, Pisarska MD, Ko JJ, Kang Y, Yoon S, Ryou SM, Cha KY, Bae J. Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Biochem Biophys Res Commun 336(3):876-881. 2005

▷ Shin JY, Suh D, Kim JM, Choi HG, Kim JA, Ko JJ, Lee YB, Kim JS, Oh YK. Low molecular weight polyethylenimine for efficient transfection of human hematopoietic and umbilical cord blood-derived CD34(+) cells. Biochem Biophys Acts 1725(3):337-384. 2005

▷ Byun HM, Suh D, Jeong Y, Wee HS, Kim JM, Kim WK, Ko JJ, Kim JS, Lee YB, Oh YK. Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells. Biochem Biophys Res Commun 332(2):518-523. 2005

▷ Yoon SC, Kim JK, Kwak DH, Ko JJ, Lee S, Choo YK, Woo WH, Jung KY. Antitumor activity of Soamsan, a traditional Korean medicine, via suppressing angiogenesis and growth factor transcription. J. Ethnopharmacol 93(2-3):403-408. 2004

▷ Oh YK, Sohn T, Park JS, Kang MJ, Choi HG, Kim JA, Kim WK, Ko JJ, Kim CK. Enhanced mucosal and systemic immunogenicity of human papillomavirus-like particles encapsidating interleukin-2 gene adjuvant. Virology 328(2):266-273. 2004

▷ BYUN HM, SUH DH, YOON H, KIM JM, CHOI HG, KIM WK, KO JJ, OH YK. Erythrocyte ghost-mediated gene delivery for prolonged and blood-targeted expression. Gene Ther 11(5):492-499. 2004

▷ Kim SJ, Lee C, Lee SY, Kim I, Park JS, Sasagawa T, Ko JJ, Park SE, Oh YK. Enhanced immunogenicity of human papillomavirus 16 L1 genetic vaccines fused to an ER-targeting secretory signal peptide and RANTES. Gene Ther 10(15):1268-1273. 2003

▷ Yoon TK, Kim TJ, Park SE, Hong SW, Ko JJ, Chung HM, Cha KY. Live births after vitrification of oocytes in a stimulated in vitro fertilization-embryo transfer program. Fertility and Sterility 79(6):1323-1326. 2003

▷ OH YK, PARK JS, KANG MJ, KO KK, KIM JM, KIM CK. Enhanced adjuvanticity of interleukin-2 plasmid DNA administered in polyethylenimine complexes. Vaccine 21:2837-2843. 2003

▷ KIM SJ, LEE C, LEE SY, KIM IH, PARK JS, Toshiyuki Sasagawa, KO JJ,PARK SE, OH YK. Enhanced immunogenicity of human papillomavirus 16 L1genetic vaccines fused to and ER-targeting secretory signal peptide and RANTES. Gene Ther 10:1268-1273. 2003

▷ Kim JK, An HJ, Kim NK, Ahn JY, Kim KS, Kang YJ, Ko JJ, Oh Do, Lee C, Kim SJ, Cha KY. IMUP-1 and IMUP-2 Genes are Upregulated in Human Ovarian Epithelial Tumors. Anticancer Res. 23:4709-4714. 2003

▷ OH YK, SUH DC, KIM JM, CHOI HG, SHIN KS, KO JJ. Polyethylenimine-mediated cellular uptake, nucleus trafficking and expression of cytokine plasmid DNA. Gene Ther 9:1627-1632. 2002

▷ BAEK KH, CHOI BC, LEE JH, CHOI HK, LEE SH, KIM JW, HILL JA, CHUNG HM, KO JJ, CHA KY. Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loos patients. Reprod Fertil Dev 14:235-240. 2002

▷ KIM YS, BAEK KH, LEE KY, CHUNG HM, LEE KA, KO JJ, CHA KY. The rgl-1 is a legitimate homologue of lethal giant larvae recessive oncogene in rat. Int. J. Oncol 20:1219-1225. 2002

▷ CHNG HM, KIM NH, KIM JW, LIM JM, KO JJ, CHA KY, CHUNG KS. Aberrant microtubule assemble and chromatin configuration of human oocytes which failed to complete fertilization following in vitro fertilization and intracytoplasmic sperm injection. J Kor Soc Anim Reprod 24. 2002

▷ BAEK KY, KIM YS, CHUNG HM, KO JJ, CHA KY. Conservation of the lethal giant larvae Tumor suppressor gene in Bos Taurus coreanae. Kor J Genetics 24:127-132. 2002

[특허]

10건의 국내특허 등록, 2건의 국외특허 출원