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Seok Ho Kim

Seok Ho Kim

전공Pharmaceutical Synthetic Chemistry, Medicinal Chemistry
연락처 031-881-7169 ksh3410@cha.ac.kr

학력

  • 서울대학교 약학대학 약학과, 약학사
  • 서울대학교 대학원 약품화학전공, 약학박사

경력

  • 서울대학교 종합약학연구소 연구원
  • 일리노이대학교 (University of Illinois at Urbana-Champaign (UIUC))
  • 차 의과학대학교 조교수 (2011 – 현재)
  • 대한약학회 재산관리위원회 간사 (2013 – 2014)
  • 대한약학회 재산관리위원회 위원 (2015 – 현재)


    • 연구실소개

    본 연구실은 다양한 생리 활성을 지닌 천연물의 전합성 및 합성 방법론에 대하여 연구하고 있다. 합성 경로 확보 후 유도체를 합성하여 다양한 치료목적을 지닌 의약품 개발을 모색한다. 다양한 골격 특히 pyrimidine 골격 및 imidazole 모핵을 가지는 화합물 라이브러리를 합성하여 생리활성을 탐색하고 화합물의 작용기전을 밝히는 연구를 수행하고 있다.

    현재 지방 세포의 분화를 조절하는 것으로 알려진 천연물의 전합성 경로를 확보하였고 유도체들을 합성하는 중이다. 항암활성을 가지는 chalcone 및 triazole 화합물들을 합성하였다. 세포보호 활성을 가지는 천연물을 전합성하여 colitis를 예방하는 약물로 개발 중이며 UV에 대한 세포 보호활성을 탐색중이다. RNA의 micro-satellite의 expansion으로 인해 MBNL-1 단백질과 결합함으로 인해서 생기는 Myotonic Dystrophy 1 질환의 치료제를 개발하고 있다. 미생물에서 특이하게 나타나는 toxin-anti-toxin system을 저분자화합물로 조절하는 새로운 개념의 항생물질을 개발하는 연구를 수행하고 있다.



    특허
  • 2,4-디아미노피리미딘을 포함하는 암의 예방 또는 치료용 조성물 출원 번호 10-2021-0097191 출원 일자 2021.07.23
  • DHPV 및 이의 광학 이성질체의 제조 방법, 및 상기 방법에 의해 제조된 DHPV의 용도 출원번호: 10-2021-0057475 출원일자: 2021.05.03

논문

    주요연구내용
  • 생리활성 천연물의 전합성
  • 치료제 개발 (Myotonic Dystrophy, 항생제, 항암제, 당뇨병)
  • 세포보호활성을 지니는 화합물 개발 (UV protection, colitis)
  • 분화조절 및 stem-toxic 저분자 화합물 발굴


    • 최근 5년간 국외 논문
  • aewoo Kim,† Haejun Oh,† Hyo-In Kim,† Yoonsu Jeon, Hyeyoung Shin, Hyun Su Kim, Juhee Lim, Changjin Lim, Jakyung Yoo, Young-Ger Suh, Woo Sung Son, Hyun jin Choi,* and Seok-Ho Kim* Discovery of New ERRγ Agonists and Dopaminergic Neuronal Phenotype Enhancement of SH-SY5Y cells Bioorganic Chemistry 2022, 122, 105716.
  • Taewoo Kim,† Hyuk Kwon,† Da-Young Lee,† Dong-Jun Kim, Yoonsu Jeon, Hyeyoung Shin, Hyun Su Kim, Joonseong Hur, Changjin Lim, Eun-Hee Kim,* Dongyun Shin,* and Seok-Ho Kim* ‘Concise Syntheses and Anti-Inflammatory Effects of Isocorniculatolide B and Corniculatolide B and C’ Bioorganic Chemistry 2021, 116, 105398.
  • Hyo In Kim, Seungbeom Lee, Juhee Lim, Sungkyun Chung, Tae-Sung Koo, Yu-Geun Ji, Young-Ger Suh, Woo Sung Son*, Seok-Ho Kim* and Hyun Jin Choi* ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic phenotype in dopaminergic neuronal cells Pharmacological Research 2021, 165, 105423 https://doi.org/10.1016/j.phrs.2021.105423
  • Taewoo Kim†, Shinyoung Cho†, Haejun Oh†, Joonseong Hur, Haedong Kim, Young-Ho Choi, Sungho Jeon, YoungDuk Yang* and Seok-Ho Kim* Discovery of 2,4-Diaminopyrimidines as Novel Anoctamin 1 (ANO1) Ion Channel Blockers Molecules 2020, 25(21), 5180; doi:10.3390/molecules25215180
  • Sooyoung Park†, Jin-Hee Kim†, Seok-Ho Kim*, and Dongyun Shin* ‘Metal-Mediated Synthesis of Arylnaphthalene Lactone’ Frontiers in Chemistry 2020, 8, 628 doi: 10.3389/fchem.2020.00628
  • Hyun Su Kim†, Sungkyun Chung†, Moon-Young Song†, Changjin Lim, Hyeyoung Shin, Joonseong Hur, Hyuk Kwon, Young-Ger Suh, Eun-Hee Kim *, Dongyun Shin * and Seok-Ho Kim * ‘Efficient, Divergent Synthesis of DHPV and Anti-Inflammatory Effect on IEC cells’ Molecules 2020, 25, 4495; doi: 10.3390/molecules25092215
  • Goyeong Choi, Seoyoung Jo, Juyeon Mun, Yonguk Jeong, Seok-Ho Kim, and Jong-Wha Jung ‘Unexpected Rearrangement of N-Allyl-2-phenyl-4,5-Dihydrooxazole-4-Carboxamides to Construct Aza-Quaternary Carbon Centers’ Molecules 2019, 24, 4495; doi:10.3390/molecules24244495
  • oung-Hyun Go, Changjin Lim, Ho-Chang Jeong, Ok-Seon Kwon, Sungkyun Chung, Haeseung Lee, Wankyu Kim, Young-Ger Suh, Woo Sung Son, Mi-Ok Lee* , Hyuk-Jin Cha* and Seok-Ho Kim* ‘Structure-activity relationship analysis of YM155 for inducing selective cell death of human pluripotent stem cells’ Frontiers in Chemistry 2019, 7, 298 doi: 10.3389/fchem.2019.00298
  • Sun-Mi Yun, Seok-Ho Kim* and Eun-Hee Kim* ‘The Molecular Mechanism of Transforming Growth Factor-β Signaling for Intestinal Fibrosis: A Mini-Review’ Frontiers in Pharmacology 2019, 10, 162 doi: 10.3389/fphar.2019.00162
  • ye-Jeong Jang,† In-Young Chung,† Changjin Lim, Sungkyun Chung, Bi-o Kim, Eun Sook Kim, Seok-Ho Kim,* You-Hee Cho* ‘Redirecting an anticancer to an antibacterial hit against methicillin-resistant Staphylococcus aureus’ Frontiers in Microbiology 2019, 10, 350 doi: 10.3389/fmicb.2019.00350
  • Sooyoung Park,† Seok-Ho Kim,† Jin-Hyun Jeong* and Dongyun Shin* Total synthesis of giffonin H by fluoride-catalyzed macrocyclization Organic Chemistry Frontier, 2019, 6, 704-708
  • Seok-Ho Kim, Shin Hee Hong, Young-Joon Park, Jong-Hyuk Sung, Wonhee Suh, Kyeong Won Lee, Kiwon Jung, Changjin Lim, Jin-Hee Kim, Hyoungsu Kim, Kyong Soo Park, Sang Gyu Park* ‘MD001, a Novel Peroxisome Proliferator-Activated Receptor α/γ agonist, Improves Glucose and Lipid Metabolism’ Scientific Reports 2019, 9, 1656
  • SeoHyun Cho,† Seok-Ho Kim† and Dongyun Shin* ‘Recent Applications of Hydantoin and Thiohydantoin in Medicinal Chemistry’ European Journal of Medicinal Chemistry 2019, 164, 517-545
  • Jaehoon Sim,† Seok-Ho Kim,† Joonseong Hur, Changjin Lim, Hyun Su Kim and Young-Ger Suh* ‘Indium(III) Triflate-Catalyzed Glycosylation via an Ambient Activation of Glycosyl Fluoride’ Asian Journal Of Organic Chemistry 2019, 8,107-110
  • Hong Pyo Kim,† Heesun Yu,† Hyoungsu Kim, Seok-Ho Kim* and Dongjoo Lee* ‘DDQ-Promoted Mild and Efficient Metal-Free Oxidative α -Cyanation of N-Acyl/Sulfonyl 1,2,3,4-Tetrahydroisoquinolines’ Molecules 2018, 23, 3023
  • Minjun Kim†, Jaebong Jang †, Goyoung Choi, Sungkyun Chung , Changjin Lim, Joonseong Hur, Hyun Su Kim, Younghwa Na, Woo Sung Son, Young-Ger Suh, Jong-Wha Jung* and Seok-Ho Kim* ‘Conversion of Medium-Sized Lactams to α-Vinyl or α-Acetylenyl Azacycles via N,O-Acetal TMS Ethers’ Molecules 2018, 23, 3023
  • ongchan An, Seungbeom Lee, Jung Min Lee, Dong Hyun Jo, Joohwan Kim, Yoo-Seong Jeong, Mi Jeong Heo, Chang Sik Cho, Hoon Choi, Ji Hae Seo, Seyeon Hwang, Jihye Lim, Taewoo Kim, Hyoung Oh Jun, Jaehoon Sim, Changjin Lim, Joonseong Hur, Jungmin Ahn, Hyun Su Kim, Seung-Yong Seo, Younghwa Na, Seok-Ho Kim, Jeewoo Lee, Jeeyeon Lee, Suk-Jae Chung, Young-Myeong Kim, Kyu-Won Kim, Sang Geon Kim, Jeong Hun Kim,* and Young-Ger Suh* ‘Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy’ J. Med. Chem., 2018, 61 (20), 9266–9286
  • Hyunyoung Moon†, Hojong Yoon†, Changjin Lim, Jaebong Jang, Jong-Jae Yi, Jae Kyun Lee, Jeeyeon Lee, Younghwa Na, Woo Sung Son, Seok-Ho Kim* and Young-Ger Suh* ‘Asymmetric Synthesis of (-)-6-Desmethyl-Fluvirucinine A1 via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions’ Molecules 2018, 23, 235
  • Ga Eun Han†, Hee-Taik Kang†, Sungkyun Chung, Changjin Lim, John A. Linton, Jin-Hee Lee, Wooki Kim, Seok-Ho Kim *,Jong Hun Lee,* ‘Novel Neohesperidin Dihydrochalcone Analogue Inhibits Adipogenic Differentiation of Human Adipose-Derived Stem Cells through the Nrf2 Pathway’ Int. J. Mol. Sci. 2018, 19(8), 2215
  • Jae-Min Cho, Sun-Mi Yun, Young-Ho Choi, Jinyuk Heo, Nam-Jung Kim, Seok-Ho Kim , Eun-Hee Kim ‘Xanthohumol prevents dextran sulfate sodium-induced colitis via inhibition of IKKβ/NF-κB signaling in mice’ Oncotarget, 2018, 9 (1), pp: 866-880
  • Joonseong Hur, Jaebong Jang, Jaehoon Sim, Woo Sung Son, Hee-Chul Ahn, Tae Sung Kim, Yern-Hyerk Shin, Changjin Lim, Seungbeom Lee, Hongchan An, Seok-Ho Kim, Dong-Chan Oh, Eun-Kyeong Jo, Jichan Jang, Jeeyeon Lee, and Young-Ger Suh* ‘Conformation-Enabled Total Syntheses of Ohmyungsamycins A and B and Structural Revision of Ohmyungsamycin B’ Angew. Chem. Int. Ed. 2018, 57, 3069 –3073

저서/역서/편서