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Jin Kyeoung Kim

Jin Kyeoung Kim

전공Molecular Pharmaceutics , RNAi-Molecular Biology
연락처 031-881-7018 kyeoung@cha.ac.kr

학력

  • 대구대학교 생물공학과 ( 공학사 )
  • 일본 히로시마대학교 종합약학과 ( 약학석사 )
  • 일본 히로시마대학교 종합약학과 ( 약학박사 )

경력

  • 충남대학교 암공동연구소 박사후연구원
  • 일본 과학기술진흥사업단 (ERATO) 연구원
  • 포천중문의과대학교 의학부 조교수 (생화학교실)
  • 포천중문의과대학교 생명과학전문대학원 부교수
  • 포천중문의과대학교 생명과학전문대학원 교학부장
  • 차 의과학대학교 약학과 학과장
  • (현) 차 의과학대학교 약학대학 교수 (생화학전공)
  • (현) 차 의과학대학교 교무처장
  • 일본 히로시마대학교 의학부 연구원
  • 일본 히로시마대학교 종합약학과 Teaching Assistant
  • 일본 정부 문부성 국가장학생
  • 한국동물학회 뉴스지 편집위원
  • 한국생화학분자생물학회 뉴스지 편집위원
  • 중소기업기술개발 지원사업 평가단 위원
  • (현) 지식경제기술혁신 평가단 위원
  • (현) 중앙약사심의위원회 전문가
  • (현) 한국약학회 약학회지 편집위원
  • (현) 한국약학교육협의회 총무재정위원회 위원


    • <특허출원>
    국외특허
  • 사람 핵단백질을 코드하는 cDNA 국외출원(2001-218585). S.Kato, J.K.Kim, R.Ryll. 2001

    • 국내특허
  • SV40에 의해 발현이 상승하는 신규 핵단백질인 IMUP-1 및 이를 암호화하는 cDNA. 국내등록(제0423550호) 김진경, 정형민, 차광렬. 2004
  • SV40에 의해 발현이 상승하는 신규 핵단백질인 IMUP-2 및 이를 암호화하는 cDNA. 국내등록(제0423549호) 김진경, 정형민, 차광렬. 2004
  • 인간 중배엽줄기세포 유래의 신규 miRNA. 국내등록 (제10-1133559호) 김진경, 정형민, 노혜민, 유중기. 2009
  • 신규한 miRNA hc-smR-S2-5 및 이의 용도. 국내등록 (제10-1308924호) 김진경, 정형민, 유중기, 이지민. 2013
  • 신규한 miRNA hc-smR-S2-3 및 이의 용도. 국내출원 (10-2013-0089718) 김진경, 유중기, 이지민, 정호용. 2013


    • 연구실 소개

    MicroRNA(miRNA)는 대략 22nt 정도로 단백질을 암호화하지 않는 small RNA이다. 이들은 표적 유잔자의 전사 후 과정에 작용하여 단백질 번역 수준을 조절하는 것으로 보고되고 있다. miRNA의 생물학적 기능은 세포의 발달, 분화, 증식, 세포사멸, 스트레스반응, 지방대사, 인슐린 분비, 발암과정 등의 광범위한 biological process에 관여한다고 보고되고 있으며, 새로운 조절 물질로 각광받고 있다.

    본 연구실은, 인간 세포를 이용하여 노화, 각종 암, 줄기세포에 특이적으로 발현하는 신규mRNA or miRNA를 cloning하여 세포 내에서의 기능을 연구하는 것을 목적으로 한다. 현재 22종의 신규 유전자와 17종의 신규 miRNA를 동정하여 각종 세포에서 특이적인 mRNA/miRNA의 database를 구축하였다. 따라서 본 연구를 통하여 각 miRNA의 고유한 기능을 밝혀내는 것은 뉴 밀레니엄 의료 바이오 산업의 성장 동력자산으로서 뿐 아니라 범 세계적 생명약학을 선도할 것으로 기대한다.

논문

    주요 연구내용

    유전자조실연구실은, 사람 세포를 이용하여 노화, 각종 암, 줄기세포에서 특이적으로 발현하는 신규 mRNA or miRNA를 cloning하여 세포 내에서의 기능을 연구 하고 있으며, 세부적으로는

  • hMSC의 대량 배양을 위한 hMSC에 존재하는 신규 mRNA/miRNA의 확인 및 기능 연구
  • 각종 암세포에 존재하는 신규 mRNA/miRNA의 확인 및 기능 연구
  • 각종 노화세포에서 특이적으로 발현하는 신규 miRNA(가칭 107)의 기능 연구
  • 유전자 진단 kit 개발을 위한 암세포에서 특이적인 신규 유전자 (imup-1,2)의 기능 연구


    • 국내논문 (* correspondence)
  • JJ Lee, JK Yoo, JK Kim, SW Son*. Expression and Purification of Unstructured Protein, IMUP-1, using Chaperone Co-expression System for NMR Study. 한국자기공명학회. 17(1):30-39. 2013
  • HN Yoo, JK Yoo, SJ Choi, JK Kim*. Expression of C6orf62 in human embryonic stem cells and cancer cells. Reprod Dev Biol. 34(3):229-233. 2010
  • 전수연, 이현정, 정현민, 김진경, 김기진*. 태반내 Immortalization-upregulated Proteins-2[IMUP-2] 발현. 대한생식의학회지. 36(3):163-173. 2009
  • KS Shin, KH Na, HJ Lee, DG Kim, SJ Shin, JK Kim, GJ Kim*. Characterization of Fetal Tissue-derived Mesenchymal Stem Cells. Int J Stem Cells. 2(1):51-58. 2009
  • JK Yoo, DR Lee, JJ Lim, JK Kim*. Expression of HBP2 in Human Spermatogonial Stem Cell-like Cells from Nonobstructive Azoospermia Patients and Its Role in G1/S Transition & Downregulation in Colon Cancer. Reprod Dev Biol. 32(4):211-215. 2008
  • JS Ahn, SH Moon, JK Yoo, HM Jung, HM Chung, JK Kim*. Expression of the C1orf31 gene in Human Stem Cells and Cancer Cells. Reprod Dev Biol. 32(4):223-227. 2008
  • HM Jung, SJ Choi, SH Kim, SH Moon, JK Yoo, HM Chung, JK Kim*. Expression of HERV-HX2 in Cancer Cells and Human Embryonic Stem Cells. Reprod Dev Biol. 32(2)105-110. 2008
  • HM Noh, SJ Choi, SH Kim, KS Kim, JK Kim*. Differential Expression of TPX2 upon Differentiation of Human Embryonic Stem Cells. Reprod Dev Biol. 31(4):221-226. 2007
  • HJ Choi, GI Kim, HJ Kim, JH Min, HM Noh, KS Kim, JK Kim*. Discovery of Differentially Overexpressed Genes in Immortalized Cells and Human Pulmonary Non-small Cell Carcinomas. J Lung Cancer. C5(2):96-101. 2006
  • JW Kim, DY Oh, SY Chong, DJ Yim, JK Kim, NK Kim*. Distributions of MTHFR Gene Polymorphism according to the Location of Colon Cancer. J Korean Soc Coloproctol. 22(2):69-74. 2006
  • JY Ahn, NM Yu, IB Han, JK Kim*. Characterization of the Differentially Expressed Novel Genes in Human Glioblastoma using Subtractive Hybridization. 대한뇌종양학회지. 4(2):1-5. 2005
  • EJ Choi, HJ An, NM Yu, JK Kim*. Characterization of the Differentially Expressed Genes in Human Breast Cancer using Subtractive Hybridization. 한국유방암학회지. 8(2):10-16. 2005
  • NM Yu, JY Ahn, EJ Choi, YK Hong, TG Kim, CH Kim, KS Lee, DS Kim, JK Kim*. Detection of Differentially Expressed Genes in Glioblastoma by Suppression Subtractive Hybridization. 대한신경외과학회지. 37(6):443-448. 2005
  • 김계성, 김진경*. 배아줄기세포를 이용한 포유류 초기 신경계 발달의 이해. 생화학분자생물학뉴스. 12:261-267. 2004
  • NM Yu, JY Ahn, KS Kim, CH Kim, TG Kim, EJ Choi, JK Kim*. Isolation and Characterization of Differentially Expressed Genes in Human Glioblastoma using Suppression Subtractive Hybridization. 대한뇌종양학회지 3(2):88-94. 2004
  • JY Ahn, JK Kim, YS Chung, SS Chung, JY Joo*. Molecular Genetic of Primary Intracerebral Hemorrhage. 대한뇌혈관외과학회지. 6(1):5-10. 2004
  • 김선희, 김남근, 조성훈, 한진희, 임동진, 곽선영, 조윤경, 김진경, 이수만, 황성규, 오도연*. 한국인 1,647명에서 Thymidylate Synthase Enhancer Region (TSER)의 유전적 다형 연구 (Genetic Polymorphisms of Thymidylate Synthase Enhancer Region (TSER) in 1,674 Koreans). 한국혈전지혈학회지. 10:11-20. 2003
  • JK Kim, DY Oh, SY K, JH Han, YS Chung, NK Kim*. Genetic Polymorphism of Vascular Endothelial Growth Factor (VEGF C936T) in Koreans. Korean J Biol Sci. 7(3):216-264. 2003
  • SC Yoon, SH Ahn, YJ Mun, JK Kim, YK Choo, KY Jung, YM Kim, WH Woo*. Studies on the Antitumor Activity of Gamisoam-san via Suppressing Angiogenesis and Growth Factor Expression. 동의생리병리학회지. 17(4):969-979. 2003
  • JY Ahn, JK Kim*. Molecular Genetics of Cerebral Aneurysm. 대한뇌혈관외과학회지. 5(1):12-16. 2003
  • JY Ahn, NK Kim, JK Kim, JY Joo, KS Lee, JU Cho*. Expression of the DNA repair gene, N-methylpurine-DNA glycosylase in astrocytic tumors. 대한신경외과학회지. 33(3):241-246. 2003
  • 윤성찬, 안성훈, 문연자, 김진경, 추영국, 정규용, 우원홍*. Studies on the antimetastasis & antiangiogenesis effects of Gamisoamsan. 대한한의학방제학회지 10(2):113-126. 2002
  • JY Ahn, NK Kim, JH Han, JK Kim, JY Joo, KS Lee*. Genetic Mutation of 5,10-Methylenetetrahydrofolate Reductase in the Brain Neoplasm. 대한신경외과학회지 32(3):183-188. 2002
  • JK Kim*. Identification of Bak-like protein cDNA. Yakhak Hoeji. 45(4):426-430. 2001
  • JK Kim*. Aging and lifespan of human somatic cells. 한국동물학회지(뉴스레터). 18(1):10-15. 2001
  • 김진경*. 게놈(Genome), 그 빛과 그림자. 차병원보. 76:14-15. 2001
  • 김삼용, 윤소현, 김현수, 김종옥, 윤환중, 김진경, 조덕연*. 항암제 처리한 백혈병 세포주에서의 Apoptosis 발현. 충남의대잡지. 25(1):177-183

    • 국외논문 (* correspondence)
  • JK Yoo, CH Kim, HY Jung, DR Lee, JK Kim*. Discovery and characterization of miRNA during cellular senescence in bone marrow-derived human mesenchymal stem cells. 58:139-145. 2014
  • HB Lee, Y Kim, H Yoo, JM Lee, YK Kim, NK Kim, JK Kim, SH oh. Blood genomic profiling in extracranial- and intracranial atherosclerosis in ischemic strock patients. 134:686-692. 2014
  • HJ Lee, JH Choi, Jung J, JK kim, SS Lee, GJ Kim. Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placent-derived mesenchymal stem cells. Cell Tissue Res. 357:145-157. 2014
  • JK Yoo, HY Jung, JM Lee, HS Yi, SH Oh, HY Ki, H Yoo, HR Kim, HS song, SH Kim*, JK Kim*. The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1. Cell Death Differ. 21:1150-11599. 2014
  • MK Park, HJ Lee, JK Choi, HJ Kim, JH Kang, YR Kim, JH Kang, JK Yoo, HY Cho, JK Kim, CH Kim, JH Park, CH Lee*. Novel anti-nociceptive effects of cardamonin via blocking expression of cyclooxygenase-2 and transglutamisase-2. Pharmacol Biochem Behav. 118:10-15. 2014
  • JK Yoo, SJ Choi, JK Kim*. Expression profiles of subtracted mRNAs during cellular senescence in human mesenchymal stem cells derived from bone marrow. Exp Gerontol. 48:464-71. 2013
  • JH Kim, SG Park, JY Song, JK Kim, JH Sung*. Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2. Cell Death & Disease4, e588; doi:10.1038/cddis.2013.117. 2013
  • SA An, J Kim, OJ Kim, JK Kim, NK Kim, J Song, SH Oh*. Limited clinical value of multiple blood markers in the diagnosis of ischemic stroke. Clin Biochem. 46(9):710-715. 2013
  • JK Yoo, HY Jung, CH Kim, WS Son, JK Kim*. miR-7641 modulates the expression of CXCL1 during endothelial differentiation derived from human embryonic stem cells. Arch Pharm Res. 36:353-8. 2013
  • SY Park, J Kim, OJ Kim, JK Kim, J Song, DA Shin, SH Oh*. Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for 3 months clinical outcome in acute cerebral infarction: multiple blood markers profiling study. Crit Care. 2013 Mar 16;17(2):R45. 2013
  • JM Lee, JK Yoo, H Yoo, HY Jung, DR Lee, HC Jeong, SH Oh, HM Chung, JK Kim*. The Novel miR-7515 Decreases the Proliferation and Migration of Human Lung Cancer Cells by Targeting c-Met. Molecular Cancer Research 11:43-53. 2013
  • SY Jeon, HJ Lee, KH Na, DH Cha, JK Kim, JW Park, TK Yoon, GJ Kim*. Hypoxia-induced downregulation of XIAP in trophoblasts mediates apoptosis via interaction with IMUP-2: Implications for placental development during pre-eclampsia. J. Cell. Biochem.114(1)89-98. 2013
  • SH Oh, MH Kim, JH Song, SY Park, OJ Kim, Hanna Yoo, YK Kim, JK Kim*. Alteration of immunologic responses on peripheral blood in the acute phase of ischemic stroke: Blood genomic profiling study. J Neuroimmunol. 249(1-2):60-65. 2012
  • JK Yoo, Jm Kim, SJ Choi, HM Noh, YD, Kwon, HN Yoo, HS Yi, HM Chung, JK Kim*. Discovery and Chracterization of Novel MicroRNAs During Endothelial Differentiation of Human Embryonic Stem Cells. Stem Cells Dev. 21(11):2049-57. 2012
  • JK Kim, KJ Choi, MH Lee, MH Jo, SH Kim*. Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin apatamer and microRNA-221 molecular beacon-conjugated nanoparticle. Biomaterials. 33:207-217. 2012
  • HN Yoo, JK Yoo, JM Lee, DR Lee, JJ Ko, SH Oh, YK Choo, JK Kim*. The hsa-miR-5787 represses cellular growth by targeting eukaryotic translation initiation factor 5 (eIF5) in fibroblast. BBRC. 415: 567-572. 2011
  • JK Yoo, JM Kim, SJ Choi, CH Kim, DR Lee, HM Chung, JK Kim*. The hsa-miR-5739 modulates the endoglin network in endothelial cells derived from human Embryonic Stem cells. BBRC. 415:258-262. 2011
  • MJ Kim, KS Shin, JH Jeon, DR Lee, SH Shim, JK Kim, DH Cha, TK Yoon, GJ Kim*. Human chorionic-palte-derived mesenchymal stem cells and Wharton’s jelly-derived mesenchymal stem cells a comparartive analysis of their potential as placenta-derived stem cells. Cell Tissue Res. 346:53-64. 2011
  • HC Jeong, EK Kim, JH Lee, JM Lee, HN Yoo, JK Kim*. Aberrant of let-7a miRNA in the blood of non-small cell lung cancer patients. MMR. 4:383-387. 2011
  • HJ Lee, KE Cha, SG Hwang, JK Kim*, GJ Kim*. In vitro screening system for hepatotoxicity: comparison of bone marrow-derived mesenchymal stem cells and placenta-derived stem cells. J. Cell. Biochem. 112(1), 49-58. 2011
  • JS Ahn, SH Moon, JM Kim, HM Chung, JK Kim*. Identification of differentially expressed genes in human embryonic stem cell derived endothelial like cells using suppression subtractive hybridization. Stem Cells Dev. 19(8):1249-1256. 2010
  • Lim JJ, Sung SY, Kim HJ, Song SH, Hong JY, Yoon TK, Kim JK, Kim KS, Lee DR*. Long-term proliferation and characterization of human spermatogonial stem cells obtained from obstructive and non-obstructive azoospermia under exogenous feeder-free culture conditions. Cell Prolif. 43(4):405-417. 2010
  • SH Oh, NK Kim, SH Kim, JK Kim, HS Kim, WC Kim, OJ Kim*. The prevalence and risk factor analysis of silent brain infarction in patients with first-ever ischemic stroke. J Neurol Sci. 293(1-2):97-101. 2010
  • SY Jeon, HJ Lee, JM Park, HM Jung, JK Yoo, HJ Lee, JS Lee, DH Cha, JK Kim, GJ Kim*. Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia. J. Cell. Biochem. 110(2):522-530. 2010
  • HM Jung, JK Kim*. Identification and characterization of WSG, a fusion gene associated with the proliferation of the WI-38 VA13 cells. Exp Lung Res. 36(3):140-147. 2010
  • JK Yoo, JJ Lim, JJ Ko, DR Lee*, JK Kim*. Expression profile of genes identified in human spermatogonial stem cell-like cells using suppression subtractive hybridization. J. Cell. Biochem 110(3):752-762. 2010
  • HM Jung, SJ Choi, JK Kim*. Expression profiles of SV40-immortalization-associated genes upregulated in various human cancers. J. Cell. Biochem. 106(4):703-713. 2009
  • SJ Kim, HJ An, HJ Kim, HM Jung, SY Lee, JJ Ko, IH Kim, N. Sakuragi, JK Kim*. IMUP-1 and IMUP-2 Overexpression in Endometrial Carcinoma in Korean and Japanese Populations. Anticancer Res. 8(2A):865-872. 2008
  • HJ An, KI Kim, JY Kim, JY Shim, HY Kang, TH Kim, JK Kim, JM Kim, SY Lee, SJ Kim*. Microsatellite instability in endometrioid type endometrial adenocarcinoma is associated with poor prognostic indicators. Am J Surg Pathol. 31(6):846-853. 2007
  • ZY Ryoo, BK Jung, SR Lee, MO Kim, SH Kim, HJ Kim, JY Ahn, TH Lee, YH Choi, JH Park, JK Kim*. Neoplastic transformation and tumorigenesis associated with overexpression of imup-1 and imup-2 genes in cultured NIH/3T3 mouse fibroblasts. BBRC. 349(3):995-1002. 2006
  • JK Kim, SH Kim, JH Han, HJ Kim, SY Chong, SP Hong, SG Hwang, JY Ahn, KY Cha, DY Oh, NK Kim*. Polymorphisms of 5, 10 – Methylenetetrahydrofolate Reductase and Risk of Stomach Cancer in a Korean Population. Anticancer Res. 25(3B):2249-2252. 2005
  • JY Ahn, SS Chung, BH Lee, SH Kim, PH Yoon, JY Joo, JK Kim*. Treatment of spontaneous arterial dissections with stent placement for preservation of the parent artery. Acta Neurochir. 147(3):265-73. 2005
  • SC Yoon, JK Kim, DH Kwak, JJ Ko, S Lee, YK Choo, WH Woo, KY Jung*. Antitumor activity of Soamsan, a traditional Korean medicine, via suppressing angiogenesis and growth factor transcription. J. Neurol. Neurosurg. Psychiatry (JNNP) 75(6):847-851. 2004
  • JK Kim, KS Kim, JY Ahn, NK Kim, HM Chung, WJ Yun, KY Cha*. Enhanced apoptosis by a novel gene, Bak-like, that lacks the BH3 domain. Biochem. Biophys. Res. Commun. (BBRC) 316:18-23. 2004
  • JK Kim, HJ An, NK Kim, JY Ahn, KS Kim, YJ Kang, JJ Ko, DY Oh, C Lee, SJ Kim, KY Cha*. IMUP-1 and IMUP-2 Genes are Upregulated in Human Ovarian Epithelial Tumors. Anticancer Res. 23:4709-4714. 2003
  • JK Kim, DY Oh, SH Cho, OJ Kim, YK Cho, SH Kim, YJ Kang, JY Ahn, SG Whang, KY Cha, NK Kim*. Genetic Polymorphisms of Thymidylate Synthase Enhancer Region (TSER) in Korean. Korea J. Genetics. 25(4):287-291. 2003
  • NK Kim, JY Ahn, JH Song, JK Kim, JH Han, HJ An, HM Chung, JY Joo, JU Choi, KS Lee, R Roy, DY Oh*. Expression of the DNA Repair Enzyme, N-Methylpurine-DNA Glycosylase (MPG) in Astrocytic Tumors. Anticancer Res. 23:1417-1424. 2003
  • DH Kwak, JK Kim, JY Kim, HY Jeong, KS Keum, SH Han, YI Rho, WH Woo, KY Jung, BK Choi, YK Choo*. Anti-angiogenic activities of Cnidium officinale Makino and Tabanus bovinus. J. Ethnopharmacol 81(3):373-379. 2002
  • HG Choi, JK Kim, DH Kwak, JR Cho, JY Kim, BJ Kim, KY Jung, BK Choi, MK Shin. YK Choo*. Effects of high molecular weight water-soluble chitosan on in vitro fertilization and ovulation in mice fed a high-fat diet. Arch.Pharm.Res. 25(2):178-183. 2002
  • KY Jung, BH Kim, MR Hwang, JR Cho, HM Kim, YC Lee, CH Kim, JK Kim, BJ Kim, YK Choo*. Differential Distribution of Ganglioside GM3 in Seminiferous Tubule and Epididymis of Adult Rats. Arch.Pharm.Res. 24(4):360-366. 2001
  • JK Kim, R Ryll, Y Ishizuka, S Kato*. Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, upregulated in SV40-immortalized human fibroblasts. Gene. 257:327-334. 2000
  • Y Shimada, M Nakano, N Kanda, K Murofushi, JK Kim, T Ide, H Morufushi*. Cell cycle-dependent activation of telomerase in naturally synchronized culture of a ture Slime Mold, Physarum polycephalum. Biochem Biophys Res. Commun. 232:492-496. 1997
  • H Tahara, K Kamada, E Sato, N Tsuyama, JK Kim, E Hara, K Oda, T Ide*. Increase in express levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan. Oncogene. 11:1125-1132. 1995
  • 김진경*. 노화세포에서 발현 변화하는 신규 유전자의 cloning. 한국교육재단 학술논총(자연과학편). 2:89-92. 1994

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