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Yeong Geo Seo

Yeong Geo Seo

전공Organic Pharmaceutical Chemistry, Medicinal Chemistry
연락처 031-850-9300 ygsuh@cha.ac.kr

학력

  • 1975 Seoul National University, B.S. in Pharmacy
  • 1980 Seoul National University, M.S. in Synthetic Pharmaceutical Chemistry
  • 1987 University of Pittsburgh, Ph.D. in Organic Chemistry

경력

  • 1987-1988 University of Pittsburgh Postdoctorial Fellow. Advisor: Professor Dennis P. Curran
  • 1988-2016 Seoul National University, College of Pharmacy. Assistant Professor, Associate Professor, Professor
  • 1992-1994 Associate Editor. Journal of the Pharmaceutical Society of Korea
  • 2001-2003 Associate Dean. College of Pharmacy, Seoul National University
  • 2003-2004 Editor-in-Chief (The Pharmaceutical Society of Korea). Archives of Pharmacal Research and Yakhak Hoeji
  • 2005-2008 Member of Editorial Board. Archives of Pharmacal Research
  • 2006-2008 Director. Korean Chemical Society
  • 2006-2009, 2015-2016 Member. Council for Korean Healthcare Technology Policy
  • 2006-2010 Director. Center for Drug Development Based on Multidisciplinary Cluster
  • 2007-2011 Dean. College of Pharmacy, Seoul National University
  • 2007-2009 President. Korean Association of College of Pharmacy
  • 2010-2016 Chairman and Member, Research Council of Korea FDA
  • 2011-2015 Director. Center for Development of Global New Drug Candidates for Vascular Diseases
  • 2012-2014 Director. Korean Accreditation Council of Pharmacy Education
  • 2012- Member of Editorial Board. Asian Journal of Organic Chemistry
  • 2013-2014 President. Korean Pharmaceutical Society
  • 2013- Fellowship. Asian Federation for Medicinal Chemistry
  • 2014-2015 President. Korean Society of Organic Synthesis
  • 2014- Vice President. The Korean Federation of Science and Technology Societies
  • 2014- Full Member. The Korean Academy of Science and Technology
  • 2016-2021 Dean. College of Pharmacy, CHA University
  • 2016 Fellow. Royal Society of Chemistry
  • 2021- Vice president, CHA University


    • [국제특허]
  • DHPV의 신규한 합성방법, 10-2003033, 2019-07-17, KR
  • 신규한 락톤 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 STAT3 관련 질환의 예방 또는 치료용 약학적 조성물, 10-1830262, 2018-02-12, KR
  • Palladino, Michael A.; Theodorakis, Emmanuel A.; Macherla, Venkat Rami Reddy; Chao, Ta-Hsiang; Suh, Young Ger. WO 2007015757 A2 “Synthesis of interleukin-1 and tumor necrosis factor-alpha modulators for therapeutic use.” PCT Int. Appl. (2007), 2007 02 08
  • Suh Young-Ger, Oh Uh Taek, Hee Doo Kim, Jee Woo Lee, Park Hyeung Geun, Park Young Ho, Yi Jung Bum; US7,067,553 B2; “Thiourea Compounds and the Pharmaceutical Compositions Containing the same”; 2006.06.27, US
  • Suh Young-Ger, Choi Young Hoon, Lee Hye Kyung, Kim Young Ho, Park Hyoung Sup; ZL99802429.5; “Diterpene Derivatives and Anti-Inflammatory Analgesic Agentss Comprising the same”; 2004.10.20, CHINA
  • Suh Young-Ger, Choi Young Hoon, Lee Hye Kyung, Kim Young Ho, Park Hyoung Sup; DE69913497 T2; “Diterpene Derivatives and Anti-Inflammatory Analgesic Agentss Comprising the same”; 2004.09.16, DEUTSCH
  • Suh Young-Ger, Choi Young Hoon, Lee Hye Kyung, Kim Young Ho, Park Hyoung Sup; 1,056,710 B1; “Diterpene Derivatives and Anti-Inflammatory Analgesic Agentss Comprising the same”; 2004.02.4, SPAIN
  • Suh Young-Ger, Choi Young Hoon, Lee Hye Kyung, Kim Young Ho, Park Hyoung Sup; EP1,056,710 B1; “Diterpene Derivatives and Anti-Inflammatory Analgesic Agentss Comprising the same”; 2003.09.12, EUROPE
  • Lee J ee Woo, Oh Uh Taek, Park Young Ho, Suh Young-Ger, Park Hyeung Geun, Hee Doo Kim, US6,476,076 B1; “Vanilloid Analogues Containing Resiniferatoxin Pharmacophores as Potent Vanilloid Receoptor Agonists and Analgesics Compositions and Uses Thereof ”; 2002.11.05, US
  • SangSup Jew, SukKu Kang , DeukJoon Kim, WonKi Kim, HwaJung Kim, ChangKiu Moon, JeongHill Park, KiHwa Jung, MoonWoo Chun, Hoon Huh, EungSeok Lee, HyungOok Kim, EunKyung Kim, SungJin Kim, JaeHoon Cheong, KwnagHo Ko, BakKwang Kim US6,030,993; ”2-Hydroxypropionic Acid Derivatives and Its Manufacturing Method”
  • Suh Young-Ger, Choi Young Hoon, Lee Hye Kyung, Kim Young Ho, Park Hyoung Sup US6593363 B1 ; “Diterpene Derivatives and Anti-Inflammatory Analgesic Agentss Comprising the same”

논문

  • Taewoo Kim,† Haejun Oh,† Hyo-In Kim,† Yoonsu Jeon, Hyeyoung Shin, Hyun Su Kim, Juhee Lim, Changjin Lim, Jakyung Yoo, Young-Ger Suh, Woo Sung Son, Hyun jin Choi,* and Seok-Ho Kim* Discovery of New ERRγ Agonists and Dopaminergic Neuronal Phenotype Enhancement of SH-SY5Y cells Bioorganic Chemistry 2022, 122, 105716.
  • Song K, Rajasekaran N, Chelakkot C, Lee HS, Paek SM, Yang H, Jia L, Park HG, Son WS, Kim YJ, Choi JS, Jeong HM, Suh YG, Yun H, Shin YK. Macrosphelide A Exhibits a Specific Anti-Cancer Effect by Simultaneously Inactivating ENO1, ALDOA, and FH. Pharmaceuticals 2021, 14 (10),1060.
  • Cho JH, Park S, Kim S, Kang SM, Woo TG, Yoon MH, Lee H, Jeong M, Park YH, Kim H, Han YT, Suh YG, Kim BH, Kwon Y, Yun H, Park BJ. RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions. Cancer Res. 2021, ASAP
  • Kim DG, Huddar S, Lim S, Kong J, Lee Y, Park CM, Lee S, Suh YG, Kim M, Lee K, Lee S, Kim S. Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2-Depleted Splice Variant of Aminoacyl-Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70. J Pharmacol Exp Ther. 2021, 379(3):358-371.
  • Kiyonga AN, Park GH, Kim HS, Suh YG, Kim TK, Jung K. An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from Ostericum koreanum (Max.) Kitagawa. Molecules. 2021, 29;26(21):6555.
  • Kim AR, Lee S, Shin JU, Seok SH, Suh YG, Kim DH. A Michael Acceptor Analogue, SKSI-0412, Down-Regulates Inflammation and Proliferation Factors through Suppressing Signal Transducer and Activator of Transcription 3 Signaling in IL-17A-Induced Human Keratinocyte. Int J Mol Sci. 22(16):8813
  • Jo DH, Lee S, Bak E, Cho CS, Han YT, Kim K, Suh YG, Kim JH. Anti-tumor Activity of Novel STAT3 Inhibitors on Retinoblastoma. Mol Pharmacol. 2021, 100(1):63-72
  • Kim SH, Yum HW, Kim SH, Kim SJ, Kim K, Kim C, Suh YG, Surh YJ. Topically Applied Taurine Chloramine Protects against UVB-Induced Oxidative Stress and Inflammation in Mouse Skin. Antioxidants. 2021, 10(6):867
  • Lee S, Kwon NH, Seo B, Lee JY, Cho HY, Kim K, Kim HS, Jung K, Jeon YH, Kim S, Suh YG. Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis. Eur J Med Chem. 2021, 218:113405.
  • Kim SH, Yum HW, Kim SH, Kim W, Kim SJ, Kim C, Kim K, Suh YG, Surh YJ. Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NFκB, STAT3, and Nrf2 as Potential Targets. Antioxidants. 2021, 10(3):479.
  • Kim EH, Kim SJ, Na HK, Han W, Kim NJ, Suh YG, Surh YJ. 15-Deoxy-Δ12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells. Cells. 2021, 10(3):526.
  • Kim SJ, Cho NC, Han B, Kim K, Hahn YI, Kim KP, Suh YG, Choi BY, Na HK, Surh YJ. 15-Deoxy-Δ12,14 -prostaglandin J2 binds and inactivates STAT3 via covalent modification of cysteine 259 in H-Ras-transformed human breast epithelial cells. FEBS Lett. 202, 595(5):604-622.
  • Kiyonga AN, Hong G, Kim HS, Suh YG, Jung K. Facile and Rapid Isolation of Oxypeucedanin Hydrate and Byakangelicin from Angelica dahurica by Using [Bmim]Tf2N Ionic Liquid. Molecules. 2021, 26(4):830.
  • Kim HI, Lee S, Lim J, Chung S, Koo TS, Ji YG, Suh YG, Son WS, Kim SH, Choi HJ. ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype. Pharmacol Res. 2021, 165:105423.
  • Kim HS, Park H, Lim J, Lim C, Kim T, Lee S, Hur J, Sim J, Choi HJ, Suh YG, Collective Syntheses of Guaiane Sesquiterpenes: Stereoselective Syntheses of (+)-Dysodensiol F, (+)-10β,14-Dihydroxy-allo-aromadendrane, and (-)-Dendroside C Aglycon, J Org Chem, 2020, 85(21):13779-13792
  • Hong SJ, Kim JT, Kim SJ, Cho NC, Kim K, Lee S, Suh YG, Cho KC, Kim KP, Surh YJ, An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target, Biomedicines, 2020, 8(10):407
  • Park SK, Byun WS, Lee S, Han YT, Jeong YS, Jang K, Chung SJ, Lee J, Suh YG, Lee SK, A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction, Biochem Pharmacol, 2020, 178:114053.
  • Kim HS, Chung S, Song MY, Lim C, Shin H, Hur J, Kwon H, Suh YG, Kim EH, Shin D, Kim SH, Efficient and Divergent Enantioselective Syntheses of DHPVs and Anti-Inflammatory Effect on IEC-6 Cells, Molecules, 2020, 25(9):2215
  • Hur J, Kim AR, Kim HS, Lim C, Kim T, Kim TA, Sim J, Suh YG, Concise Synthesis of Catechin Metabolites 5-(3′,4′-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities, Molecules, 2020, 25(8):1970
  • Sivaraman A, Kim DG, Bhattarai D, Kim M, Lee HY, Lim S, Kong J, Goo JI, Shim S, Lee S, Suh YG, Choi Y, Kim S, Lee K, Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy, J Med Chem, 2020, 63(10):5139-5158
  • Lee S, Kim DG, Kim K, Kim T, Lim S, Kong H, Kim S, Suh YG, 2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment, J Med Chem, 2020, 63(8):3908-3914
  • More KN, Lee YJ, Kim KJ, Suh YG, Son YJ, Chang DJ, Effect of TRPV1 Antagonist SC0030, a Potent Painkiller, on RANKL-mediated Osteoclast Differentiation Involved in Bone Resorption, Bull. Korean Chem. Soc, 2020, 41:488-491
  • Jeong YS, Baek M, Lee S, Kim MS, Maeng HJ, Lee JH, Suh YG, Chung SJ, Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry, Molecules, 2020, 25(3):531
  • Jeong M, Lee H, Kim G, Jo J, Chang JW, Jung JH, Suh YG, Yun H, Divergent Synthetic Route to Oxidized Benzofulvene Sesquiterpenoids: Protecting-Group-Free Total Synthesis of Nicotianasesterpenes A, B, and a Polygonum Sesquiterpenoid, Eur. J. Org. Chem, 2019, 39:6714–6719
  • Lim C, Park JG, Kang KB, Suh YG, Identification and Semi-Synthesis of 3-O-Protocatechuoylceanothic Acid, a Novel and Natural GPR120 Agonist, Molecules, 2019, 24(19):3487
  • Jo J, Jeong M, Ahn JS, Akter J, Kim HS, Suh YG, Yun H, Total Synthesis of Anmindenol A and Its Application to the Design, Synthesis, and Biological Evaluation of Derivatives Thereof, J Org Chem, 2019, 84(17):10953-10961
  • Kiyonga AN, An JH, Lee KY, Lim C, Suh YG, Chin YW, Jung K, Rapid and Efficient Separation of Decursin and Decursinol Angelate from Angelica gigas Nakai using Ionic Liquid, (BMIm)BF4, Combined with Crystallization, Molecules, 2019, 24(13):2390
  • Go YH, Lim C, Jeong HC, Kwon OS, Chung S, Lee H, Kim W, Suh YG, Son WS, Lee MO, Cha HJ, Kim SH, Structure-Activity Relationship Analysis of YM155 for Inducing Selective Cell Death of Human Pluripotent Stem Cells, Front Chem, 2019, 7:298
  • Ko H, Lee JH, Kim HS, Kim T, Han YT, Suh YG, Chun J, Kim YS, Ahn KS, Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer, Biomolecules, 2019, 9(5):170
  • Lee EJ, Kim SJ, Hahn YI, Yoon HJ, Han B, Kim K, Lee S, Kim KP, Suh YG, Na HK, Surh YJ, 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression, Redox Biol, 2019, 23:101175
  • Kim HS, Hoang VH, Hong M, Chul Kim K, Ann J, Nguyen CT, Seo JH, Choi H, Yong Kim J, Kim KW, Sub Byun W, Lee S, Lee S, Suh YG, Chen J, Park HJ, Cho TM, Kim JY, Seo JH, Lee J, Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents, Bioorg Med Chem, 2019, 27(7):1370-1381
  • Sim J, Kim SH, Hur J, Lim C, Kim HS, Suh YG, Indium(III) Triflate Catalyzed Glycosylation via an Ambient Activation of Glycosyl Fluoride, Asian Journal of Organic Chemistry, 2019, 8:107-110.
  • Kim M, Jang J, Choi G, Chung S, Lim C, Hur J, Kim HS, Na Y, Son WS, Suh YG, Jung JW, Kim SH, Conversion of Medium-Sized Lactams to α-Vinyl or α-Acetylenyl Azacycles via N,O-Acetal TMS Ethers, Molecules. 2018, 23(11). pii: E3023.
  • An JH, Youn W, Kiyonga AN, Lim C, Park M, Suh YG, Ryu HC, Kim JS, Park CW, Jung K, Kinetics of the Solution-Mediated Polymorphic Transformation of the Novel L-Carnitine Orotate Polymorph, Form-II, Pharmaceutics. 2018, 10(4). pii: E171.
  • An H, Lee S, Lee JM, Jo DH, Kim J, Jeong YS, Heo MJ, Cho CS, Choi H, Seo JH, Hwang S, Lim J, Kim T, Jun HO, Sim J, Lim C, Hur J, Ahn J, Kim HS, Seo SY, Na Y, Kim SH, Lee J, Lee J, Chung SJ, Kim YM, Kim KW, Kim SG, Kim JH, Suh YG*, Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy, Journal of Medicinal Chemistry, 2018, 61(20):9266-9286.
  • Moon H, Yoon H, Lim C, Jang J, Yi JJ, Lee JK, Lee J, Na Y, Son WS, Kim SH* and Suh YG*, Asymmetric Synthesis of (−)-6-Desmethyl-Fluvirucinine A1 via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions, Molecules 2018, 23(9), 2351.
  • An JH, Lim C, Kiyonga AN, Chung IH, Lee IK, Mo K, Park M, Youn W, Choi WR, Suh YG, Jung K, Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors, Pharmaceutics, 2018, 10(3). pii: E149.
  • Munhyung Bae, Jedo Oh, Eun Seo Bae, Joonseok Oh, Joonseong Hur, Young-Ger Suh, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh* “WS9326H, an Antiangiogenic Pyrazolone-Bearing Peptide from an Intertidal Mudflat Actinomycete” Org. Lett. 2018, 20, 1999-2002
  • Jinyoung Suh, Do-Hee Kim, Eun-Hee Kim, Sin-Aye Park, Jong-Min Park, Jeong-Hoon Jang, Su-Jung Kim, Hye-Kyung Na, Nam-Doo Kim, Nam-Jung Kim, Young Ger Suh, Young-Joon Surh* “15-Deoxy-D12,14-prostaglandin J2 activates PI3K-Akt signaling inhuman breast cancer cells through covalent modification of the tumorsuppressor PTEN at cysteine 136” Cancer Lett. 2018, 424, 30-45
  • Jaebong Jang, Sooyoung Chung, Youjeong Choi, Hye Young Lim, Yeongeon Son, Sung Kook Chun, Gi Hoon Sone, Kyungjin Kim, Young-Ger Suh⁎, Jong-Wha Jung* “The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex” Life Sci. 2018, 200, 49-55
  • Wonki Kim, Seung Hyeon Kim, Jeong-Hoon Jang, Chaekyun Kim, Kyeojin Kim, Young-Ger Suh, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, Young-Joon Surh* “Role of heme oxygenase-1 in potentiation of phagocytic activity ofmacrophages by taurine chloramine: Implications for the resolution ofzymosan A-induced murine peritonitis” Cell. Immunol. 2018, 327, 36-46
  • Joonseong Hur, Jaebong Jang, Jaehoon Sim, Woo Sung Son, Hee-Chul Ahn, Tae Sung Kim, Yern-Hyerk Shin, Changjin Lim, Seungbeom Lee, Hongchan An, Seok-Ho Kim, Dong-Chan Oh, Eun-Kyeong Jo, Jichan Jang, Jeeyeon Lee, and Young-Ger Suh* “Conformation-Enabled Total Syntheses of Ohmyungsamycins A and B and Structural Revision of Ohmyungsamycin B” Angew. Chem. Int. Ed. 2018, 57, 3069-3073
  • Hyun Su Kim, Taewoo Kim, Jungmin Ahn, Hwayoung Yun, Changjin Lim, Jaebong Jang, Jaehoon Sim, Hongchan An, Young-Joon Surh, Jeeyeon Lee, Young-Ger Suh* “Asymmetric Total Synthesis of (+)-(3E)-Pinnatifidenyne via Abnormally Regioselective Pd(0)-Catalyzed Endocyclization” J. Org. Chem. 2018, 83, 1997-2005.
  • Jaehoon Sim, Hyunkyung Park, Juhee Lim, Inah Yoon, Changjin Lim, Hongchan An, Hwayoung Yun, Hyun Jin Choi, and Young-Ger Suh* “Stereoselective Synthesis of 1,4,5-Tri-cis-guaiane Sesquiterpene: First Total Synthesis of (-)-Dendroside C Aglycon.” Org. Lett. 2018, 20, 586-589
  • Seung Hyeon Kim, Xiancai Zhong, Wonki Kim, Kyeojin Kim, Young-Ger Suh, Chaekyun Kim, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, and Young-Joon Surh* “Taurine chloramine potentiates phagocytic activity of peritoneal macrophages through up-regulation of dectin-1 mediated by heme oxygenase-1-derived carbon monoxide” FASEB J. 2018, 32, 2246-2256
  • Changjin Lim, Jungmin Ahn, Jaehoon Sim, Hwayoung Yun, Joonseong Hur, Hongchan An, Jaebong Jang, Seungbeom Lee, and Young-Ger Suh* “Total synthesis of (+)-brasilenyne via concise construction of an oxonane framework containing a 1,3-cis,cis-diene” Chem. Commun. 2018, 54, 467-470

저서/역서/편서