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문지숙

문지숙 교수

전공Stem cell, Bioinformatics
연락처 031-881-7120 jmoon@cha.ac.kr

학력

  • Cornell Univ. Ph.D. Neuroscience (2006.08)
  • Cornell Univ. MA, Biostatistics (2006.08)
  • Yonsei Univ. BA, Psychology (2001.02)

경력

  • Cornell Univ. Post-Doctoral researcher (2006.08-2006.11)
  • Cornell Univ. Visiting Fellow Scientist (2006.11-현재)
  • Harvard Medical School Post-Doctoral researcher (2006.11-2008.12)
  • Harvard Medical School Visiting Fellow Scientist (2009.01-현재)
  • CHA Univ. Clinical Statistics Center Director (2009.01-2016.12)
  • Seoul CRO, Statistics Department, Director (2009.10~2015.12)
  • CHA Univ. Dep. of Biotechnology Associate professor (2009.01-현재)
  • CHA Univ. Anti-aging Center Director (2011.01-현재)
  • CHA Univ. Dep. of Biotechnology 학과장 (2017.12-2019.03)
  • CHA Univ. Global Center, Director (2019.03-현재)
  • CHA Group Research Center, NPC Center, Director (2018.12~현재)
  • CHA Bio Tech, NPC Research Center, Director (2015.01~현재)
  • 차의과학대학교 글로벌교류센터 센터장


    • [프로젝트]
  • 치매진단기기 개발
  • 노화진단기기 개발
  • 파킨슨치료제 개발
  • 치매치료제 개발


    • [대외활동]
  • 충남도 바이오융합산업 특별위원회, 위원
  • 미세먼지 학회, 학회임원


    • [수상]
  • KASBP , 최우수 연구상
  • NIH National Graduate Student Research Festival, 2006
  • Paula E. Faurerbach Fellowship: Cornell University, 2005
  • Katherine Wyckoff Harris Fellowship: Cornell University, 2004

논문

    주요연구내용
  • 태아 중뇌유래 신경전구세포 이용 신경질환 치료제 개발
  • 태반 유래 줄기세포를 이용한 항노화 및 신경질환 치료제 개발
  • Bioinformatics and Statistics


    • [SELECTED PUBLICATIONS (LAST 5 YEARS)]
  • Kim KS, Kim HS, Park JM, Kim HW, Park MK, Lee HS, Lim DS, Lee TH, Chopp M, J Moon. Long-term Immunomodulatory Effect of Amniotic Stem Cells in Alzheimer’s Disease Model. Neurobiology of Aging, in press
  • Jeong JY, Kim KS, Moon JS, Song JA, Choi SH, Kim KI, Kim TH, An HJ. Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers. Apoptosis.18(4):509-20. 2013 Apr
  • Kim, J.S. Kim, H.-J.Moon, J. Choi, Y.Y. Kang, J.H. Lim, S.M. Kim, K.M. Assessment of Early Phase -FP-CIT PET as an Alternative Method of FDG PET for Voxel Based Statistical Analysis: Application for Parkinson’s Disease Rat Model. IEEE TNS, 99 (1), 2013
  • Han HW, Bae SH, Jung YH, Moon J. Genome-wide characterization of the relationship between essential and TATA-containing genes. FEBS LETTERS,1;587(5):444-51.2013
  • Moon J, Lee HS, Kang J, Park J, Leung A, Hong S, Chung S, Kim KS. Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson’s disease, the aphakia mouse Cell Transplant. 2012 Oct 2
  • Jeon I, Lee N, Li JY, Park IH, Park KS, Moon J, Shim SH, Choi C, Chang DJ, Kwon J, Oh SH, Shin DA, Kim HS, Do JT, Lee DR, Kim M, Kang KS, Daley GQ, Brundin P, Song J. Neuronal properties, in vivo effects, and pathology of a Huntington’s disease patient-derived induced pluripotent stem cells. Stem Cells. 2012 Sep;30(9):2054-62
  • Bae SH, Lee HS, Kang MS, Strupp SJ, Chopp M, Moon J.The Levels of Pro-Inflammatory Factors Are Significantly Decreased in Cerebral Palsy Patients Following an Allogeneic Umbilical Cord Blood Cell Transplant. International Journal of Stem Cells Vol. 5, No. 1, 2012
  • Bae SH, Kong TH, Lee HS, Kim KS, Hong KS, Chopp M, Kang MS, Moon J.Long-lasting paracrine effects of human cord blood cells (hUCBCs) on damaged neocortex in an animal model of cerebral palsy. Cell Transplant. 2012 Apr 17.
  • Kim YS, Kim EY, Moon J,Yoon TK, Lee WS, Lee KA. Expression of interferon regulatory factor-1 in the mouse cumulus-oocyte complex is negatively related with oocyte maturation. Clin Exp Reprod Med. 2011 Dec;38(4):193-202.
  • Moon J, Chen M, Gandhy S, Strawderman M, Levitsky D, Maclean KN, Strupp BJ. Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome. Behav Neurosci in press
  • Lee HS, Kim EY, Kim KH, Moon J, Park KS, Kim KS, Lee KA.Obox4 critically regulates cAMP-dependent meiotic arrest and MI-MII transition in oocytes FASEB, Feb2010.
  • Joung Y, Kim C-H, Moon J,JangW-S,YangJ,ShinD,Lee Sand Kim K-S. Association Studies of -3081[A/T] Polymorphism of Norepinephrine Transporter Gene With Attention Deficit/Hyperactivity Disorder in Korean Population. AmericanJournalofMedicalGenetics. Neuropsychiatric Genetics. Part B. 153B, 691-694 2010
  • Riccio A, Li Y, Moon J, KimK-S, Gapon S,Yao GL,Tsvetkov E,Rodig S,Meloni EG,Carlezon WA,Clapham DE,Bolshakov VY.Essential role for TRPC5 in amygdale function and fear-related behavior. Cell.137,761-772 May 2009
  • Ardayfio P, Moon J, Leung KK, Youn-Hwang D, Kim KS.Impaired learning and memory in Pitx3 deficient aphakia mice: A genetic model for striatum-dependent cognitive symptoms in Parkinson’s disease. NeurobiolDis.31,406-412Jun2008
  • Moon J, Ota, K, Levitsky DA, Crnic LS, Strupp BJ. A mouse model of fragile X syndrome exhibits heightened arousal and/or emotion following errors or reversal of contingencies. DevPsychobiol.2008 Jul;50(5):473-85.
  • McNaughton CH, Moon J, Strawderman MS, Maclean KN, Evans J, Strupp BJ. Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome. Behav Neurosci. 2008 Apr;122(2):293-300.
  • Moon J, AE Beaudin,S Verosky,M.Weiskopf,LL Driscoll,DA Levitsky,LS Crnic,BJ Strupp.Evidence for impairment in attention,inhibitory control,and arousal regulation in fmr1 mutant mice:a model of Fragile X syndrome.BehavNeurosci.2006 Dec;120(6):1367-79
  • Driscoll LL, Carroll JC, Moon J,Crnic LS, Levitsky DA, Strupp BJ. Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse:a mouse model of Down syndrome and Alzheimer’s disease. BehavNeurosci.2004 Dec;118(6):1196-205

    • [SELECTED PRESENTATIONS]
  • Bae SH, Han HW, Kim HW, Moon J. Subnetwork-based analysis of human diseases in protein complex X with housekeeping functions. Translational Bioinformatics Conference 2012.
  • Kim HW, Han HW, Bae SH, Moon J. Genome-wide characterization of the aging-related genes compare with the disease and essential genes. Translational Bioinformatics Conference 2012.
  • Hyun Wook Han, Chan Hee Park, Hyun-Seob Lee, Ju Han Kim, Moon J. Relationship between Perturbation Sensitivity of genes and genomic structrue. 2011 3th Joint educational Workshop for MD/DDS-PhD, Physician-Scientist Workshop (Jan 23-25 2011, Korea).
  • H. Lee, HW Kim, J. Kang, B. Kim, MY Sung, HM Jung, KY Cha, KS Kim, Moon J. Human term placental stem cells derived Neural progenitor cells (hPSC-NPCs) prevent neuronal cell death via an extrinsic paracrine mechanism. 40th Annual meeting Neuroscience 2010 (Nov 13-17 2010, USA).
  • Sang-Hun Bae, Tae-Ho Kong, Hyun-Seob Lee, Kyung-Sul Kim, Han-Wool Kim, Myung-Seo Kang, Min-Young Kim, Jisook Moon. Motor, Cognition,a nd Emotional Functions in Cerebral Hypoxic-iscemic Damaged Neonatal Rats are Recovered by Paracrine effect of Human Cord Blood mononuclear Cells. 2010 Seoul Symposium on Stem Cell Research (Aug 25 2010, Korea).
  • Bona Kim, Hyun-Seob Lee, Sigrid Schwarz, Mi Young Sung, Su-Kang Kong, Young Eun Lee, Kwang-Yul Cha, Johannes Schwarz, Kwang-Soo Kimm, Jisook Moon. Enhanced Dopaminergic Differentiation of Human Midbrain-derived Neural Progenitor Cells in a Model of Parkinson Disease in Rats. 2010 Seoul Symposium on Stem Cell Research (Aug 25 2010, Korea).
  • Jisook Moon, Kwang-Soo Kim, Han Wool Kim, Hyun-Seob Lee, Junmo Kang. Human term placental epithelial stem cells derived Oct4 non-expressing NPCs are alternative cell therapeutic sources for CNS diseases. ISSCR 8th Annual meeting (June 16-19 2010, USA).
  • Jisook Moon Kwang-Soo Kim, Hyun-Seob Lee, Bona Kim, Su-Kang Kong, Mi Young Sung, Young eun Lee, Johannes Schwarz, Sigrid Schwarz. Novel and simple culture system of human fetal NPCs for cell transplantation of Parkinson Disease on a large clinical scale. ISSCR 8th Annual meeting (June 16-19 2010, USA).
  • Moon J and Kim K-S: Stem cell transplantation ameliorates behavioral impairments of the aphakia mouse, a new genetic model of Parkinson Disease (PD), Accepted in Society for Neuroscience 37th Annual Meeting, Nov 2007. San Diego.
  • J. MOON, SD. GINSBERG, S GANDHY, K MACLEAN, M. IKONOMOVIC, EJ MUFSON, BJ STRUPP: Perinatal choline supplementation reduces cognitive decline and increases cortical choline acetyltransferase activity in the Ts65Dn mouse model of Down syndrome & Alzheimer’s Disease. Neuroscience 37th Annual Meeting, Nov 2007. San Diego.
  • Moon J, Chen M, Crnic LS, Maclean K.N., Strupp BJ. Perinatal choline supplementation ameliorates attentional dysfunction in the Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer’s disease. Accepted in Society for Neuroscience 36th Annual Meeting, Oct 2006. Atlanta.
  • Moon J, Maclean K.N., Strupp BJ. Beneficial Effect of Perinatal Choline Supplementation on Attentional Dysfunction in the Ts65Dn Mouse: a Mouse Model of Down syndrome and Alzheimer’s Disease Submitted in NIH Poster Festival, Oct 2006. Washington, DC.
  • Moon J, Beaudin AE, Driscoll LL, Levitsky DA, LS Crnic LS, Strupp BJ. Impaired Executive Function in FMR1 Knockout mice. The Neurobehavioral Teratology Society, July 2006, Tuscon, AZ, USA.
  • Moon J, Beaudin AE, Weiskopf M, Driscoll LL, Levitsky DA, LS Crnic LS, Strupp BJ. Impaired performance of FMR1 Knockout mice two sustained attention tasks: Evidence for deficient inhibitory control and adaptability to change. Society for Neuroscience 35th Annual Meeting, November 2005. Washington, DC
  • Strupp BJ, Moon J, Beaudin AE, Verosky S, Driscoll LL, Levitsky DA, Crnic LS Assessment of Selective Attention and Error Reactivity in FMR1 Knockout Mice: A Mouse Model of Fragile X Syndrome (FXS). The Neurobehavioral Teratology Society, October 2005, Gainesville, Florida.
  • Moon J, Beaudin AE, Verosky S, Driscoll LL, Levitsky DA, LS Crnic LS, Strupp BJ. Evidence for impairments in attention, inhibitory control, and arousal regulation in fmr1 mutant mice: a model of Fragile X syndrome. Society for Neuroscience 34th Annual Meeting, October 2004 San Diego, CA.
  • Moon J, Driscoll LL, Crnic LS, Strupp BJ. Assessment of Selective Attention and Error Reactivity in Aged Ts65Dn Mice: A Mouse Model of Down’s Syndrome (DS) and Alzheimer’s Disease (AD), Society for Neuroscience 33th Annual Meeting, October 2003 New Orleands, LA.

저서/역서/편서