송행석

인사말

송행석교수

전문분야 |  생식생리학, 분자발생학
(En)
Molecular Reproductive Physiology, Molecular Developmental Biology

전화번호 | 031-881-7150
E – mail | hssong@cha.ac.kr

학력

한양대학교 (생물학과), B.S.
한양대학교 (생물학과), M.S.
미국 University of Kansas Medical Center (분자생리학과), Ph.D.

주요경력

미국 Washington University at St. Louis 박사후연구원
관동의대 제일병원 의학연구소 연구실장, 의학과 조교수
차 의과학대학교 의생명과학과, 조교수
(현) 차 의과학대학교 의생명과학과, 부교수

한국발생생물학회 총무이사
(현) 대한의생명과학회 학술간사
(현) 한국발생생물학회 산학협력위원장
(현) 대한생식의학회 학술위원

주요연구내용

1. 다낭성난포증후군 (PCOS)이 환자의 자궁 기능 이상에 미치는 연구
2. 유전자결핍생쥐모델(Gene targeted mouse model)들을 이용하여 특정 유전자 및 microRNA가 배아 착상 및 자궁 기능에 미치는 영향에 관한 연구
3. 착상 전 초기 배아 발달에 관여하는 유전자들의 기능에 대한 연구 등을 생식생리학 및 분자생물학적 관점에서 연구하고 있습니다.

(SCI 국외 논문)

1. Song H, Lim H, Das SK, Paria BC and Dey SK (2000) Dysregulation of EGF family of growth factors and cyclooxygenase-2 in the uterus during the preattachment and attachment reactions of the blastocyst correlates with implantation failure in LIF deficient mice. Mol Endocrinol 14(8):1147-1161 (제1저자)

2. Paria BC, Song H, Dey SK (2001) Implantation: Molecular basis of embryo-uterine dialogue. Intl J Dev Biol 45(3):597-605

3. Paria BC, Song H, Wang X, Schmid PC, Krebsbach RJ, Schmid HHO, Bonner TI, Zimmer A, Dey SK (2001) Dysregulated endocannabinoid signaling disrupts uterine receptivity for embryo implantation. J Biol Chem 276(23):20523-20528

4. Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN, Dey SK (2001) Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J Biol Chem 276(47):44137-44145

5. Lim H, Song H, Paria BC, Reese J, Das SK, Dey SK (2002) Molecules in blastocyst implantation: uterine and embryonic perspectives Vitamins and Hormones 64:43-76.

6. Song H, Lim H, Paria BC, Matsumoto H, Swift LL, Morrow JD, Bonventre JV, Dey SK (2002). Cytosolic phospholipase A2 alhpa is critical to “on-time” embryo implantation that directs subsequent development. Development 129(12):2879-2889 (제1저자)

7. Ma W, Song H, Das SK, Paria BC, Dey SK (2003). Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci USA 100(5): 2963-2968

8. Daikoku T, Song H, Guo Y, Riesewijk A, Mosselman S, Das SK, Dey SK (2004). Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: Evidence for a novel cytokine-homeobox-Wnt signaling in implantation. Mol Endocrinol 18(5):1238-1250

9. Koo TB, Song H, Moon I, Han K, Chen C, Murphy K, Lim H (2005). Differential expression of the PEA3 subfamily of ETS transcription factors in the mouse ovary and peri-implantation uterus. Reproduction 129(5):651-657

10. Song H, Lim H (2006). Evidence for heterodimeric association of LIFR and gp130 in the mouse uterus for LIF signaling during blastocyst Implantation. Reproduction 131(2):341-349 (제1저자)

11. Lim JJ, Lee DR, Song H, Kim KS, Yoon TK, Gye MC, Kim MK (2006). HB-EGF may improve embryonic development and implantation by increasing vitronectin receptor expression in peri-implantation mouse embryos. J Assist Reprod Genet 23(3):111-119

12. Song H, Han K, Lim H (2007). Progesterone supplementation extends uterine receptivity for blastocyst implantation in mice. Reproduction 133(2):487-493 (제1저자)

13. Han K, Song H, Moon I, Augustin R, Moley KH, Rogers M, Lim H (2007). Utilization of DR1 as true RARE in regulating the Ssm, a novel retinoic acid-target gene in the mouse testis. J Endocrinol 192(3):539-551

14. Zhang B, Jain S, Song H, Fu M, Heuckeroth R, Erlich J, Jay P, Milbrandt J (2007). Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development 134(17):3191-3201

15. Ding T, Song H, Wang X, Khatua A, Paria BC (2008). Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus). Reproduction 135(1):41-53

16. Eo J, Han K, Murphy K, Song H, Lim H (2008) Etv5, an ETS transcription factor, is expressed in granulosa and cumulus cells and serves as a transcriptional regulator of the cyclooxygenase-2. J Endocrinol 198(2):281-290

17. Lee SH*, Song H*, Park YS, Koong MK, Song IO, Jun JH (2009) Poor sperm quality affects clinical outcomes of ICSI in fresh and subsequent frozen-thawed ET cycles: Potential paternal effects on pregnancy outcomes. Fertil Steril 91(3):798-804 (*공동제1저자)

18. Kim JY, Song H, Kim H, Kang HJ, Jun JH, Hong SR, Koong MK, Kim IS (2009) Transcriptional profiling with a pathway-oriented analysis identifies dysregulated molecular phenotypes in the endometrium of patients with polycystic ovary syndrome. J Clin Endocrinol Metab 94(4):1416-1426 (교신저자)

19. Song H*, Zhang B*, Watson MA. Humphrey PA, Lim H, Milbrandt J (2009) Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 28(37): 3307-3319 (*공동제1저자)

20. Shin SY, Song H, Kim CG, Choi YK, Lee KS, Lee SJ, Lee HJ, Lim Y, Lee YH (2009) Egr-1 is necessary for fibroblast growth factor-2-induced transcriptional activation of the glial cell line-derived neurotrophic factor in murine astrocytes. J Biol Chem 284(44):30583-30593

21. Hong SH, Lee JE, Jung JJ, Hwang SJ, Bae SN, Choi JY, Song H (2010) Small proline-rich protein 2 family is a cluster of genes induced by estrogenic compounds through nuclear estrogen receptors in the mouse uterus. Reproductive Toxicology 30:469-476 (교신저자)

22. Kang JH*, Song H*, Yoon JA, Park DY, Kim SH, Lee KJ, Farina A, Cho YK, Kim YN, Park SW, Kim GJ, Shim SH, Cha DH (2011) Preeclamsia leads to dysregulation of various signaling pathways in placenta. Journal of Hypertension 29:928-936 (*공동제1저자)

23. Lee JE, Oh HA, Song H, Jun JH, Roh CR, Xie H, Dey SK, Lim H (2011) Autophagy regulates embryonic survival during delayed implantation. Endocrinology 152:2067–2075

24. Eo J, Shin H, Kwon S, Song H, Murphy KM, Lim HJ (2011) Complex ovarian defects lead to infertility in Etv5-/- female mice. Mol Hum Reprod (In Press)

25. Kang HJ, Hwang SJ, Yoon JA, Jun JH, Lim H, Yoon TK, Song H (2011) Activation of peroxisome proliferators activated receptor d (PPARd) promotes blastocyst hatching in mice. Mol Hum Reprod 17(10):653-660 (교신저자)

26. Jo J*, Song H*, Park SG, Lee SH, Ko JJ, Park JH, Jeong J, Cheon YP, Lee DR (2012) Regulation of differentiation potential of human mesenchymal stem cells by intracytoplasmic delivery of coactivator-associated arginine methyltransferase 1 protein using cell-penetrating peptide. Stem Cells 30:1703-1713 (*공동제1저자)

27. Lyu SW*, Song H*, Yoon JA, Chin MU, Sung SR, Kim YS, Lee WS, Yoon TK, Cha DH, Shim SH (2013) Transcriptional profiling with a pathway-oriented analysis in the placental villi of unexplained miscarriage. Placenta 34:133-140 (*공동제1저자) (This work was highlighted as cover)

28. Shin H, Song H, Suh CS, Lim HJ (2013) The formin protein mDia2 serves as a marker of spindle pole dynamics in vitrified-warmed mouse oocytes. PlosOne 8(9):e75729

29. Yu HK, Lee HJ, Choi HN, Ahn JH, Choi JY, Song H, Lee KH, Yoon Y, Yi LSH, Kim JS, Kim SJ, Kim TJ (2013) Characterization of CD45-/CD31+/CD105+ Circulating Cells in the Peripheral Blood of Patients with Gynecologic Malignancies. Clin Can Res 19(19):5340-5350

30. Choi S, Shin H, Song H, Lim HJ (2014) Suppression of autophagic activation in the mouse uterus by estrogen and progesterone. J of Endocrinol 221(1):39-50 (교신저자)

31. Shin H, Kwon S, Song H, Lim HJ (2014) The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes. PlosOne 9(4):e94708

32. Lee HA, Kim HR, Lee YJ, Lee SJ, Kim WJ, Han SS, Yang SR, Woo HM, Na S, Song H, Hong SH (2014) Immunolocalization and estrogen regulation of small proline-rich protein 2a protein in the mouse uterus. Reprod Fertil Dev 26(5):682-689 (교신저자)

33. Yoo JK, Jung HY, Lee JM, Yi H, Oh SH, Ko HY, Yoo H, Kim HR, Song H, Kim S, Kim JK (2014) The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1. Cell Death and Differentiation 21(7):1150-1159

34. Bang S, Shin H, Song H, Suh CS, Lim HJ (2014) Autophagic activation in vitrified-warmed mouse oocytes. Reproduction 148(1):11-19

35. Lim HJ, Song H (2014) Evolving tales of autophagy in early reproductive events. Int J Dev Biol 58:183-187 (교신저자)

36. Kim HR, Kim YS, Yoon JA, Lyu SW, Shin H, Lim HJ, Hong SH, Lee DR, Song H (2014) Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus. Reprod Toxicol 50:60-67 (교신저자)

37. Jeong JH, Park M, Park M, Lim EJ, Kim HR, Song H, Park SG, Choi SJ, Hong KH, Lee DR, Ko JJ, Choi Y (2015) The expression of aminoacyl-tRNA-synthetase-interacting multifunctional protein-1 (Aimp1) is regulated by estrogen in the mouse uterus. Mol Cell Endocrinol 399:78-86

38. An B, Na S, Lee S, Kim WJ, Yang SR, Woo HM, Kook S, Hong Y, Song H, Hong SH (2015) Non-enzymatic isolation followed by supplementation of basic fibroblast growth factor improves proliferation, clonogenic capacity and SSEA-4 expression of perivascular cells from human umbilical cord. Cell Tissue Res 359(3):767-777

39. Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ,

Lydon JP, Choi Y, Lee DR, Song H (2016) Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Sci Rep 6:20242 (교신저자)

40. Bae S, Kwon H, Yoon H, Park M, Kim HR, Song H, Hong K, Choi Y. Estrogen-dependent expression of sine oculis homeobox 1 in the mouse uterus during the estrous cycle. Biochem Biophys Res Commun 472(3):489-495

41. Kim HR, Lee JH, Yang SR, Song H, Hong SH (2016) Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway. Cell & Bioscience (In press) (교신저자)

42. Choi Y, Kim HR, Lim EJ, Park M, Yoon JA, Kim YS, Kim EK, Shin JE, Kim JH, Kwon H, Song H, Choi DH (2016) Integrative analyses of uterine transcriptome and microRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients with recurrent/repeated implantation failure (RIF). PLoS ONE (In press) (교신저자)

(국내논문)

1. Song H (2006). Lessons from mouse models to understand uterine receptivity for embryo implantation. Korean J Fertil Steril 33(3):139-148 (교신저자)

2. Han SC, Song H, Jun JH (2008) Establishment and characterization of multi-potent germ line stem cells (MGSCs) from neonatal mouse testis. Korean J Reprod Med 35(1):39-48

3. Eo J, Song H, Lim HJ (2012) Etv5, a transcription factor with versatile functions in male reproduction Clin Exp Reprod Med 39(2):41-45

4. Seo BJ, Son JW, Kim HR, Hong SH, Song H (2014) Identification of Egr1 direct target genes in the uterus by in silico analyses with expression profiles from mRNA microarray data. Development and Reproduction 18(1):1-11

(En)

Education

Department of Biology, Hanyang University (B.S.)
Department of Biology, Hanyang University (M.S.)
Department of Molecular and Integrative Physiology, University of Kansas Medical Center (Ph.D.) (USA)

Academic Appointment
Post-doc, Department of Pathology and Immunology, Washington University in St. Louis (USA)
Senior Scientist and Scientific Director, Cheil General Hospital and Women’s Healthcare Center, Kwandong University College of Medicine
Assistant Professor, Department of Biomedical Science, CHA University
Associate Professor, Department of Biomedical Science, CHA University

Secretory General, Korean Society of Developmental Biology
Scientific board member, Korean Society for Biomedical Laboratory Sciences
Scientific board member, Korean Society of Developmental Biology

Research Interest

1. Functional understanding of CFP1-dependent epigenome on uterine physiology and embryo implantation
2. Molecular mechanisms of autophagy for embryo implantation in the uterus using Tsg101 conditional knockout mice
3. Function of microRNAs in uterine biology using Dgcr8 conditional knockout mice
4. Development of therapeutic protocols to treat severe Asherman Syndrome using perivascular stem cells

Publication

1. Song H, Lim H, Das SK, Paria BC and Dey SK (2000) Dysregulation of EGF family of growth factors and cyclooxygenase-2 in the uterus during the preattachment and attachment reactions of the blastocyst correlates with implantation failure in LIF deficient mice. Mol Endocrinol 14(8):1147-1161
2. Paria BC, Song H, Dey SK (2001) Implantation: Molecular basis of embryo-uterine dialogue. Intl J Dev Biol 45(3):597-605
3. Paria BC, Song H, Wang X, Schmid PC, Krebsbach RJ, Schmid HHO, Bonner TI, Zimmer A, Dey SK (2001) Dysregulated endocannabinoid signaling disrupts uterine receptivity for embryo implantation. J Biol Chem 276(23):20523-20528
4. Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN, Dey SK (2001) Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J Biol Chem 276(47):44137-44145
5. Lim H, Song H, Paria BC, Reese J, Das SK, Dey SK (2002) Molecules in blastocyst implantation: uterine and embryonic perspectives. Vitamins and Hormones 64:43-76.
6. Song H, Lim H, Paria BC, Matsumoto H, Swift LL, Morrow JD, Bonventre JV, Dey SK (2002). Cytosolic phospholipase A2a is critical to “on-time” embryo implantation that directs subsequent development. Development 129(12):2879-2889
7. Ma W, Song H, Das SK, Paria BC, Dey SK (2003). Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci USA 100(5): 2963-2968
8. Daikoku T, Song H, Guo Y, Riesewijk A, Mosselman S, Das SK, Dey SK (2004). Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: Evidence for a novel cytokine-homeobox-Wnt signaling in implantation. Mol Endocrinol 18(5):1238-1250
9. Koo TB, Song H, Moon I, Han K, Chen C, Murphy K, Lim H (2005). Differential expression of the PEA3 subfamily of ETS transcription factors in the mouse ovary and peri-implantation uterus. Reproduction 129(5):651-657
10. Song H, Lim H (2006). Evidence for heterodimeric association of LIFR and gp130 in the mouse uterus for LIF signaling during blastocyst Implantation. Reproduction 131(2):341-349
11. Lim JJ, Lee DR, Song H, Kim KS, Yoon TK, Gye MC, Kim MK (2006). HB-EGF may improve embryonic development and implantation by increasing vitronectin receptor expression in peri-implantation mouse embryos. J Assist Reprod Genet 23(3):111-119
12. Song H, Han K, Lim H (2007). Progesterone supplementation extends uterine receptivity for blastocyst implantation in mice. Reproduction 133(2):487-493
13. Han K, Song H, Moon I, Augustin R, Moley KH, Rogers M, Lim H (2007). Utilization of DR1 as true RARE in regulating the Ssm, a novel retinoic acid-target gene in the mouse testis. J Endocrinol 192(3):539-551
14. Zhang B, Jain S, Song H, Fu M, Heuckeroth R, Erlich J, Jay P, Milbrandt J (2007). Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development 134(17):3191-3201
15. Ding T, Song H, Wang X, Khatua A, Paria BC (2008). Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus). Reproduction 135(1):41-53
16. Eo J, Han K, Murphy K, Song H, Lim HJ (2008) Etv5, an ETS transcription factor, is expressed in granulosa and cumulus cells and serves as a transcriptional regulator of the cyclooxygenase-2. J Endocrinol 198(2):281-290
17. Lee SH*, Song H*, Park YS, Koong MK, Song IO, Jun JH (2009) Poor sperm quality affects clinical outcomes of ICSI in fresh and subsequent frozen-thawed ET cycles: Potential paternal effects on pregnancy outcomes. Fertil Steril 91(3):798-804 *These authors equally contribute to this work
18. Kim JY, Song H, Kim H, Kang HJ, Jun JH, Hong SR, Koong MK, Kim IS (2009) Transcriptional profiling with a pathway-oriented analysis identifies dysregulated molecular phenotypes in the endometrium of patients with polycystic ovary syndrome. J Clin Endocrinol Metab 94(4):1416-1426 (Corresponding author)
19. Song H, Zhang B, Watson MA. Humphrey PA, Lim H, Milbrandt J (2009) Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 28(37): 3307-3319
20. Shin SY, Song H, Kim CG, Choi YK, Lee KS, Lee SJ, Lee HJ, Lim Y, Lee YH (2009) Egr-1 is necessary for fibroblast growth factor-2-induced transcriptional activation of the glial cell line-derived neurotrophic factor in murine astrocytes. J Biol Chem 284(44):30583-30593
21. Hong SH, Lee JE, Jung JJ, Hwang SJ, Bae SN, Choi JY, Song H (2010) Small proline-rich protein 2 family is a cluster of genes induced by estrogenic compounds through nuclear estrogen receptors in the mouse uterus. Reproductive Toxicology 30:469-476 (Corresponding author)
22. Kang JH*, Song H*, Yoon JA, Park DY, Kim SH, Lee KJ, Farina A, Cho YK, Kim YN, Park SW, Kim GJ, Shim SH, Cha DH (2011) Preeclampsia leads to dysregulation of various signaling pathways in placenta. Journal of Hypertension 29:928-936 *These authors equally contribute to this work
23. Lee JE, Oh HA, Song H, Jun JH, Roh CR, Xie H, Dey SK, Lim HJ (2011) Autophagy regulates embryonic survival during delayed implantation. Endocrinology 152(5):2067–2075
24. Eo J, Shin H, Kwon S, Song H, Murphy KM, Lim HJ (2011) Complex ovarian defects lead to infertility in Etv5-/- female mice. Mol Hum Reprod 17(9):568-576
25. Kang HJ, Hwang SJ, Yoon JA, Jun JH, Lim H, Yoon TK, Song H (2011) Activation of peroxisome proliferators activated receptor d (PPARd) promotes blastocyst hatching in mice. Mol Hum Reprod 17(10):653-660 (Corresponding author)
26. Jo J*, Song H*, Park SG, Lee SH, Ko JJ, Park JH, Jeong J, Cheon YP, Lee DR (2012) Regulation of differentiation potential of human mesenchymal stem cells by intracytoplasmic delivery of coactivator-associated arginine methyltransferase 1 protein using cell-penetrating peptide. Stem Cells 30:1703-1713 *These authors equally contribute to this work
27. Lyu SW*, Song H*, Yoon JA, Chin MU, Sung SR, Kim YS, Lee WS, Yoon TK, Cha DH, Shim SH (2013) Transcriptional profiling with a pathway-oriented analysis in the placental villi of unexplained miscarriage. Placenta 34:133-140 *These authors equally contribute to this work (This work was highlighted as cover)
28. Shin H, Song H, Suh CS, Lim HJ (2013) The formin protein mDia2 serves as a marker of spindle pole dynamics in vitrified-warmed mouse oocytes. PLoS ONE 8(9):e75729
29. Yu HK, Lee HJ, Choi HN, Ahn JH, Choi JY, Song H, Lee KH, Yoon Y, Yi LSH, Kim JS, Kim SJ, Kim TJ (2013) Characterization of CD45-/CD31+/CD105+ Circulating Cells in the Peripheral Blood of Patients with Gynecologic Malignancies. Clin Can Res 19(19):5340-5350
30. Choi S, Shin H, Song H*, Lim HJ* (2014) Suppression of autophagic activation in the mouse uterus by estrogen and progesterone. J of Endocrinol 221(1):39-50 (Corresponding author) *These authors equally contribute to this work
31. Shin H, Kwon S, Song H, Lim HJ (2014) The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes. PLoS ONE 9(4):e94708
32. Lee HA, Kim HR, Lee YJ, Lee SJ, Kim WJ, Han SS, Yang SR, Woo HM, Na S, Song H*, Hong SH* (2014) Immunolocalization and estrogen regulation of small proline-rich protein 2a protein in the mouse uterus. Reprod Fertil Dev 26(5):682-689 (Corresponding author) *These authors equally contribute to this work
33. Yoo JK, Jung HY, Lee JM, Yi H, Oh SH, Ko HY, Yoo H, Kim HR, Song H, Kim S, Kim JK (2014) The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1. Cell Death and Differentiation 21(7):1150-1159
34. Bang S, Shin H, Song H, Suh CS, Lim HJ (2014) Autophagic activation in vitrified-warmed mouse oocytes. Reproduction 148(1):11-19
35. Lim HJ*, Song H* (2014) Evolving tales of autophagy in early reproductive events. Int J Dev Biol 58:183-187 (Corresponding author) *These authors equally contribute to this work
36. Kim HR, Kim YS, Yoon JA, Lyu SW, Shin H, Lim HJ, Hong SH, Lee DR, Song H (2014) Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus. Reprod Toxicol 50:60-67 (Corresponding author)
37. Jeong JH, Park M, Park M, Lim EJ, Kim HR, Song H, Park SG, Choi SJ, Hong KH, Lee DR, Ko JJ, Choi Y (2015) The expression of aminoacyl-tRNA-synthetase-interacting multifunctional protein-1 (Aimp1) is regulated by estrogen in the mouse uterus. Mol Cell Endocrinol 399:78-86
38. An B, Na S, Lee S, Kim WJ, Yang SR, Woo HM, Kook S, Hong Y, Song H, Hong SH (2015) Non-enzymatic isolation followed by supplementation of basic fibroblast growth factor improves proliferation, clonogenic capacity and SSEA-4 expression of perivascular cells from human umbilical cord. Cell Tissue Res 359(3):767-777
39. Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ, Lydon JP, Choi Y, Lee DR, Song H (2016) Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Sci Rep 6:20242 (Corresponding author)
40. Bae S, Kwon H, Yoon H, Park M, Kim HR, Song H, Hong K, Choi Y (2016). Estrogen-dependent expression of sine oculis homeobox 1 in the mouse uterus during the estrous cycle. Biochem Biophys Res Commun 472(3):489-495
41. Choi Y, Kim HR, Lim EJ, Park M, Yoon JA, Kim YS, Kim EK, Shin JE, Kim JH, Kwon H, Song H*, Choi DH* (2016) Integrative analyses of uterine transcriptome and microRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients with recurrent/repeated implantation failure (RIF). PLoS ONE 11(6): e0157696 (Corresponding author) *These authors equally contribute to this work
42. Kim HR, Lee JH, Yang SR, Song H*, Hong SH* (2016) Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway. Cell & Bioscience 6(1):50 (Corresponding author) *These authors equally contribute to this work
43. Park J, Shin H, Song H*, Lim HJ* (2016) Autophagic regulation in steroid hormone-responsive systems. Steroids 115:177-181 (Corresponding author) *These authors equally contribute to this work
44. Shin H, Bang S, Kim J, Jun JH, Song H, Lim HJ (2017) The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice. Sci Rep 7:41986
45. Kim HR, Cho KS, Kim E, Lee OH, Yoon H, Lee S, Moon S, Park M, Hong K, Na Y, Shin JE, Kwon H, Song H, Choi DH, Choi Y (2017) Rapid expression of RASD1 is regulated by estrogen receptor-dependent intracellular signaling pathway in the mouse uterus. Mol Cell Endocrinol 446:32-39
46. Kim J*, Song H*, Heo HR*, Kim JW, Kim HR, Hong Y, Yang SR, Han SS, Lee SJ, Kim WJ, Hong SH (2017) Cadmium-induced ER stress and inflammation are mediated through C/EBP-DDIT3 signaling in human bronchial epithelial cells. Experimental & Molecular Medicine (In press) *These authors equally contribute to this work
47. An B, Kim E, Song H, Ha KS, Han ET, Park WS, An TG, Yang SR, Na S, Hong SH (2017) Gestational diabetes affects the growth and functions of perivascular stem cells. Mol Cells (In press)