나영화

인사말

나영화 교수

전문분야 |의약화학, 의약품 합성
전화번호 | 031-881-7164
E – mail | yna7315@cha.ac.kr

​학력

 

1985-1989 : 영남대학교 약학대학, 학사
1989-1991 : 영남대학교 약학과, 석사
1996-2000 : University of Houston, Ph. D.
2001-2002 : University of Arizona, Post Doc.

주요경력

 

2004.09.-2011.01: 대구가톨릭대학교 약학대학

2011.02.-현재: 차 의과학대학교 약학대학

2011.09. – 2014.02: 종합약학연구소 소장

2014.03. – 2016.02: 약학과 및 대학원 학과장

 

주요연구내용

1. Melanin 생합성 저해기능의 피부미백제 개발
2. Topoisomerase를 타겟으로 한 항암제 개발
3. CK2 저해제 개발
4. Chalcone 유도체 합성과 생리활성 연구

 

연구실 소개

본 연구실은 새로운 신약후보 물질 발굴을 위하여 유기합성과 약물학적 활성 연구를 이용하여 다양한 구조의 합성 또는 천연물 유래 생리활성 화합물들의 전합성 또는 구조 변경 및 최적화 연구를 수행하고 있다.

연구분야로는 topoisomerase와 PKCK2효소 기능을 억제하여 항암효과를 가지는 유도체들을 합성을 통하여 연구개발하고 있으며, 약물학적 활성 및 작용기전을 공동 연구진들과 함께 수행하고 있다. 또한 천연에서 유래하는 licochalcone E  및 chalcone 화합물의 약물학적 활성 연구 결과를 바탕으로 구조변환 작업을 수행하여 새로운 항염증, 항산화 및 항치매 효능을 가지는 신약후보물질 도출을 위한 연구를 수행하고 있다.
이외에도 피부미백제, 위장관 기능조절제, 항당뇨 기능등의 생리활성 후보 물질들을 발굴하고 새로운 신약후보물질로 개발하기 위한 의약화학적 연구를 수행하고 있다.

[최근5년간 논문]

 

1. Kyung-Hwa Jeon, Eunyoung Lee, Kyu-Yeon Jun, Ji-Eun Eom, Soo Yeon Kwak, Younghwa Na, Youngjoo Kwon Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against -calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation Eur. J. Med. Chem. 2016, Accepted. (20160608).

2. Soo-Yeon Park, Younghwa Na, Mee-Hee Lee, Jae-Sung Seo, Yoo-Hyun Lee, Kyung-Chul Choi, Hyo-Kyoung Choi, Ho-Geun Yoon SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth Oncotarget, 2016 (20160426)

3. Kyung Hye Baek, Han Vit Yu, Eosu Kim, Younghwa Na, Youngjoo Kwon Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway Oncotarget, 2016 , 21 (7) 30831-30844(20160418)

4. Radha Karki, Kyu-Yeon Jun, Tara Man Kadayat, Somin Shin, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee, A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study Eur. J. Med. Chem. 2016, 113, 228-245. (20160504).

5. Pritam Thapa, Tara Man Kadayat, Seojeong Park, Somin Shin, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents Bioorg. Chem. 2016, 66, 145-159.

6. Tara Man Kadayat, Seojeong Park, Kyu-Yeon Jun, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee. Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines Bioorg. Med. Chem. 2016, 26(7), 1726-1731. (20160401)

7. Eun-Jung Bak, Kyung-Chul Choi, Sungil Jang, Gye-Hyeong Woo, Ho-Geun Yoon, Younghwa Na, Yun-Jung Yoo,  Youngseok Lee, Yangsik Jeong, Jeong-Heon Cha, Licochalcone F alleviates glucose tolerance and chronic inflammation in diet-induced obese mice through Akt and p38 MAPK, Clinical Nutrition, 2016, 35(2), 414-421.(20160401)

8. Tara Man Kadayat, Chanju Song, Somin Shin, Til Bahadur, Thapa Magar, Ganesh Bist, Aarajana Shrestha, Pritam Thapa, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of 2-phenyl- or hydroxylated 2- phenyl-4-aryl-5H-indeno[1,2-b]pyridines Bioorg. Med. Chem. 2015, 23(13), 3499-3512. (20150701)

9. Radha Karki,, Chanju Song,] Tara Man Kadayat, Til Bahadur Thapa Magar, Ganesh Bist, Aarajana Shrestha, Younghwa Na, Youngjoo Kwon, Eung-Seok Lee Topoisomerase I and II inhibitory activity, cytotoxicity, andtructure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines, Bioorg. Med. Chem. 2015, 23(13), 3638-3654. (20150701)

10. Kwon, Han Byeol; Park, Chanmi; Jeon, Kyung-Hwa; Lee, Eunyoung; Park, So-Eun; Jun, Kyu-Yeon; Kadayat, Tara Man; Thapa, Pritam; Karki, Radha; Na, Younghwa; Park, Mi Sun; Rho, Seung Bae; Lee, Eung-Seok; Kwon, Youngjoo A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases. J. Med. Chem. 2015, 58 (3), 1100–1122.

11. Song Wha Chae, Sangwook Woo,Jung Hyun Park,Youngjoo Kwon,Younghwa Na, Hwa Jeong Lee Xanthone Analogues as Potent Modulators of Intestinal P-glycoprotein, Eur. J. Med. Chem. 2015, 93, 237-245.

12. Soo-Yeon Park, Mi-Jeong Kim, Young Jun Kim, Yoo-Hyun Lee, Donghyuk Bae, Sunoh Kim, Younghwa Na, Ho-Geun Yoon Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation in Aß-induced Alzheimer’s model. Int. J. Mol. Med. 2015, 35(4), 1109-1118.

13. Cheng-Hao Jin, Kyu-Yeon Jun, Eunjung Lee, Seongrak Kim,, Youngjoo Kwon, Kunhong Kim, Younghwa Na Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor, Bioorg. Med. Chem. 2014, 22 (17), 4553-4565

14. Kyung Hye Baek, Radha Karki, Eung-Seok Lee, Younghwa Na, Youngjoo Kwon Synthesis and Investigation of Dihydroxychalcones as Calpain and Cathepsin Inhibitors, Bioorg. Chem. 2013, 51, 24-30. (Co-corresponding)

15. So-Eun Park, In-Hye Chang, Kyu-Yeon Jun, Eunyoung Lee, Eung-Seok Lee, Younghwa Na, Youngjoo Kwon 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase II catalytic inhibitor with low DNA damage, Eur. J. Med. Chem 2013, 69, 139-145. (Co-corresponding)

16. Jung Min Nam, Kyung-Hwa Jeon, Hanbyeol Kwon, Eunyoung Lee, Kyu-Yeon Jun, Yeung Bae Jin, Yun-Sil Lee, Younghwa Na, Youngjoo Kwon, Dithiiranylmethyloxy azaxanthone shows potent anti-tumor activity via suppression of HER2 expression and HER2-mediated signals in HER2-overexpressing breast cancer cells, European Journal of Pharmaceutical Sciences, 2013, 50(2), 181-190. (Co-corresponding)

17. Seok-Ho Kim, Eunyoung Lee, Kyung Hye Baek, Han Byeol Kwon, Hyunjung Woo, Eung-Seok Lee, Youngjoo Kwon, Younghwa Na. Chalcones, Inhibitors for Topoisomerase I and Cathepsin B and L, as Potential Anti-cancer Agents. Bioorg. Med. Chem. Lett.. 2013, 23, 3320-3324.

특허 (국내)

 

1. 항암제 조성물 (2016) 등록번호: 10-1615009, 등록일자: 2016. 04. 18

2. 신규한 칼콘 유도체 및 이의 용도 (2013) 출원번호 10-2013-0071218. 출원일자 2013. 06. 20

3. PCAF 저해제를 유효성분으로 함유하는 퇴행성 뇌질환의 예방 및 치료용 조성물 (2014) 출원번호 10-2014-013465. 출원일자 2014. 09. 29

4. 신규한 항암제 보조용 화합물, 이의 제조방법 및 이를 포함하는 항암제 보조용 조성물 (2013), 등록번호: 10-1326900-0000, 등록일자: 2013.11.01

5. 갈릭산 유도체를 유효성분으로 함유하는 항암 조성물, 대한민국 (2013), 등록번호: 10-1286153-0000, 등록일자: 2013.07.09

6. 신규한 화합물, 이의 제조방법 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물, 대한민국 (2013), 등록번호: 10-1281955-0000, 등록일자: 2013.06.27

7. 토포아이소머라제 (topoisomerase) Ⅰ및 Ⅱ 활성 억제제로 유용한 신규한 2,4-디페닐-6-아릴 피리딘 계 화합물, 이의 제조방법 및 이를 포함하는 조성물, 대한민국, (2012) 등록번호: 10-1182058-0000

8. 리코칼콘계 화합물의 제조방법, 대한민국 (2010), 등록번호: 10-0963899-0000

 

 

특허 (국제)

 

1. ANTICANCER-AIDING COMPOUND, METHOD FOR PREPARING THE SAME, ANTICANCER-AIDING COMPOSITION CONTAINING THE SAME AND METHOD FOR REDUCING ANTICANCER DRUG RESISTANCE USING THE SAME; US patent (2014), Patent No. US 8,846,749 B2. 등록일자: 2014. 09. 30.