​학력

B.S. in Pharmacy, College of Pharmacy, Chonnam National University
M.S. in Biopharmaceutics, College of Pharmacy, Chonnam National University
Ph.D. in Biopharmaceutics, College of Pharmacy, Chonnam National University
Post-doc. Department of Pharmaceutics, State University of New York at Buffalo, USA

주요경력

(현) Associate Professor, College of Pharmacy, CHA University
(현) Affiliate Professor, Graduate School of Clinical Pharmacy, CHA University
Deputy Director, Korea Food & Drug Administration (KFDA)
Research Professor, Chonnam National University Hospital Clinical Trial Center
Research Assistant, College of Pharmacy, Chonnam National University
Researcher, Research Institute of Drug development, Chonnam National University
General Manager, Embiel Co. Ltd
Pharmacist, IlYang Pharm. Co. Ltd
Pharmacist, DAEWON Pharm. Co. Ltd

(현) 식품의약품안전처 중앙약사심의위원회 위원
(현) 식품의약품안전처 건강기능식품 심의위원회 위원
(현) 보건복지부 (재)한국임상시험산업본부 분과위원
(현) 한미약학자연합회(KAPSA) Editorial Secretary
(현) 대학연구윤리협의회 집행이사
(현) (사)한국약제학회 학술위원장
(현) Journal of Pharmaceutical Investigation 편집위원
(현) (사)한국FDC(Food, Drug & Cosmetic) 법제학회 학술위원장
(현) 식품의약품안전평가원 PBPK Working group 전문가위원
(현) SCI-C Regulatory Affair (RA) 분과 Medical Reviewer
(현) American Association of Pharmaceutical Scientists (AAPS) 정회원
(현) International Society for the Study Xenobiotics (ISSX) 정회원
(현) Population Approach Group in Korea (PAGK) 운영위원
(현) 한국약제학회 평의원
(현) 대한약학회 정회원(약제학 분과)
(현) 질량분석학회 정회원
CHA Group 연구총괄본부 임상연구실장
보건복지부 국가임상시험사업단 분과위원
(사) 한국FDC(Food, Drug & Cosmetic) 법제학회 재무위원장
(사) 한국응용약물학회 홍보간사

<논문>
1. Hea-Young Cho, Chong Ki Lee and Yong-Bok Lee, Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery, J. Nanomater., 2016, 1-14 (2016)

2. Seo-Hee Heo, Dong-Seok Lee, Seong-Ho Ham, Jung-Hee Cho, Young-Dal Kwon, Yong-Bok Lee and Hea-Young Cho, Pharmacokinetic evaluation of paeoniflorin after oral administration of Paeoniae Radix extract powder to healthy Korean subjects using UPLC-MS/MS, J. Pharm. Invest., 46(3), 273-282 (2016)

3. Hea-Young Cho, Chong Ki Lee and Yong-Bok Lee, Preparation and Evaluation of PEGylated and Folate-PEGylated Liposomes Containing Paclitaxel for Lymphatic Delivery, J. Nanomater., 2015, 1-10 (2015)

4. Hea-Young Cho, Ji-Hoon Choi, In-Joon Oh and Yong-Bok Lee, Self-emulsifying drug delivery system for enhancing bioavailability and lymphatic delivery of tacrolimus, J. Nanosci. Nanotechnol., 15, 1831-1841 (2015)

5. Sook-Jin Kim, Sang-Hyuk Lee, Yong-Soo Kim, Hyo-Rin Jung and Hea-Young Cho, A rapid and selective LC-MS/MS method for the quantification of aripiprazole in beagle dog plasma and its application to a pharmacokinetic study. J. Pharm. Invest., 44(6), 465-472 (2014)

6. Hyo-Rin Jung, Sook-Jin Kim, Seong-Ho Ham, Jung-Hee Cho, Yong-Bok Lee and Hea-Young Cho, Simultaneous determination of puerarin and its active metabolite in human plasma by UPLC-MS/MS: Application to a pharmacokinetic study, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 971, 64-71 (2014)

7. Hea-Young Cho and Yong-Bok Lee, Nano-sized drug delivery systems for lymphatic delivery. Review, J. Nanosci. Nanotechnol., 14, 868-880 (2014)

8. Hea-Young Cho, Geun-Kyeong Park and Yong-Bok Lee, Simultaneous determination of morniflumate and its major active metabolite, niflumic acid, in human plasma by high-performance liquid chromatography in stability and pharmacokinetic studies, Biomed. Chromatogr., 27, 1438-1443 (2013)

9. Hea-Young Cho*, Hwa Yoon*, Hee-Doo Yoo, Se-Mi Kim and Lee YB, Influences of Organic Cation Transporter polymorphisms on the population pharmacokinetics of metformin in healthy subjects, AAPS Journal, 15, 571-580 (2013) (DOI : 10.1208/s12248-013-9460-z) *equal contributed author

10. Yoo HD*, Cho HY*, Lee SN, Yoon H and Lee YB, Population pharmacokinetic analysis of risperidone and 9-hydroxyrisperidone with genetic polymorphisms of CYP2D6 and ABCB1, J. Pharmacokinet. Pharmacodyn., 39, 329-341 (2012) *equal contributed author

11. Hee-Doo Yoo, Sang-No Lee, Hyun-Ah Kang, Hea-Young Cho, Il-Kwon Lee, and Yong-Bok Lee, Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of risperidone in healthy subjects with CYP2D6*10/*10, Brit. J. Pharmacol., 164, 433-443 (2011)

12. Hee-Doo Yoo, Mi-Suk Kim, Hea-Young Cho and Yong-Bok Lee, Population pharmacokinetic analysis of glimepiride with CYP2C9 genetic polymorphism in healthy Korean subjects, Eur. J. Clin. Pharmacol., 67, 889-898 (2011)

13. Dong-Min Kim, Yoon Seong Kim, Hea-Young Cho, and Yong-Bok Lee, Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi, Diagnostic Microbiology & Infectious Disease, 69, 271-274 (2011)

14. Eun Yong Chung, Hea-Young Cho, Ji-Hun Cha, Kyoung-Jin Kwon, Seol-Hee Jeon, Su Hyun Jo, Eun-Jung Kim, Hye Soo Kim and Hye Ju Chung, Inhibitory Effect of Nicardipine on hERG Channel, Biomolecules & Therapeutics, 18(4), 448-453 (2010)

15. H.Y. Cho, H.D. Yoo and Y.B. Lee, Influence of ABCB1 Genetic Polymorphisms on the Pharmacokinetics of Levosulpiride in Healthy Subjects, Neuroscience, 169, 378-387 (2010)

16. Kim MY, Seo EJ, Lee DH, Kim EJ, Kim HS, Cho HY, Chung EY, Lee SH, Baik EJ, Moon CH and Jung YS, Gadd45beta is a novel mediator of cardiomyocyte apoptosis induced by ischaemia/hypoxia, Cardiovasc. Res., 87(1), 119-126 (2010)

17. Hwa Yoon, Hea-Young Cho, and Yong-Bok Lee, Determination of ibudilast in human serum by high-performance liquid chromatography for pharmacokinetic study, Biomed. Chromatogr., 24(3), 324-328 (2010)

18. Sae-Byeok Shin, Hea-Young Cho, Dae-Duk Kim, Han-Gon Choi and Yong-Bok Lee, Preparation and evaluation of tacrolimus-loaded nanoparticles for lymphatic delivery, Eur. J. Pharm. Biopharm., 74(2), 164-171 (2010)

19. Hee-Doo Yoo, Hea-Young Cho and Yong-Bok Lee, Population pharmacokinetic analysis of cilostazol in healthy subjects with genetic polymorphisms of CYP3A5, CYP2C19 and ABCB1, British. J. Clin. Pharmacol., 69(1), 27-37 (2010)

20. Cho HY, Blum RA, Sunderland T, Cooper GJ, Jusko WJ, Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults, J. Clin. Pharmacol., 49(8), 916-928 (2009)

21. H.Y. Cho, H. Yoon, Y.C. Lim and Y.B. Lee, Pharmacokinetics and bioequivalence evaluation of gliclazide/metformin combination tablet and equivalent doses of gliclazide and metformin in healthy Korean subjects, Int. J. Clin. Pharmacol. Ther., 47(12), 770-779 (2009)

22. Cho WS, Cho M, Jeong J, Choi M, Cho HY, Han BS, Kim SH, Kim HO, Lim YT, Chung BH and Jeong J, Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles, Toxicol. Appl. Pharmacol.. 236(1), 16-24 (2009)

23. Hea-Young Cho, Hwa Yoon, Geun-Kyeong Park, and Yong-Bok Lee, Pharmacokinetics and Bioequivalence of Two Formulations of Rebamipide 100-mg Tablets; A Randomized, Single-Dose, Two-Period, Two-Sequence Crossover Study in Healthy Korean Male Volunteers, Clinical Therapeutics, 31(11), 2712-2721 (2009)

24. Hee-Doo Yoo, Sun-Ae Park, Hea-Young Cho and Yong-Bok Lee, Influence of CYP3A and CYP2C19 genetic polymorphisms on the pharmacokinetics of cilostazol in healthy subjects, Clin. Pharmacol. Ther., 86(3), 281-284 (2009)

[수상경력]

NAGAI Foundation Awards, Controlled Release Society, 2001.06.27
우수학술포스터상, 한국약제학회, 2001.11.15
우수논문발표상, 대한약학회, 2003.10.18
학술장려상, 한국약제학회, 2006.11.30
업무유공자상(차관급표창), 식품의약품안전청, 2010.01.04
제25회 과학기술 우수논문상, 한국과학기술단체총연합회, 2015.07.02
산학기술상, 한국약제학회, 2015.11.19

[주요연구내용]
1. 신약개발 후보 물질 등의 체내동태에 관한 연구
2. 약동학 분석을 이용한 약물의 disposition 특성에 관한 연구
3. 펩티드성 약물의 약물속도론적 약력학적 모델 구축에 관한 연구
4. 천연물제제 등의 안전성․유효성 평가를 위한 1상 임상연구
5. 대사효소 및 약물수송체의 polymorphism을 고려한 약물유전체 연구
6. 의약품/의료기기 허가 등 관련 법령의 규제 분야 해설 등
[연구실 소개]
약물을 체내에 투여하게 되면 흡수 (absorption, A), 분포 (distribution, D), 대사 (metabolism, M) 및 배설 (elimination, E) 등의 과정을 거치게 되는데 이러한 ADME 과정을 속도론적 입장에서 해석하는 학문이 약물속도론 (pharmacokinetics)입니다. 모델을 가정하여 투약 후의 혈중농도, 소실반감기, 대사속도, 배설속도 및 축적량 등을 정량적으로 예측함으로써 ① 생체 내에서의 약물현상의 기구를 해명하고, ② 투여량, 투여간격 및 투여 제형을 적절히 결정하며, ③ 나아가서는 보다 유효하고 안전성이 높은 의약품의 개발에 기여하고자 하는 것을 목적으로 합니다.

우리 연구실은 동물실험에서 약물의 체내동태를 속도론적으로 해석하여 분포용적, 속도정수 등의 파라미터를 산출한 후 animal scale-up의 방법으로 동물 데이터로부터 사람의 약물동태를 예측하고, 또한 약물 농도(PK)와 약물 효과(PD)를 연결할 수 있는 모델 구축 연구를 수행하고 있어, 실제 환자에게 약물의 효과가 충분히 발휘되고 안전성이 확보되도록 하는 약물 투여 용법 적정화에 기여할 수 있을 것으로 기대하고 있습니다.

<특허>
L-THP를 유효성분으로 포함하는 약물남용 치료제(2011.07.28) (등록번호: 제10-1054093호)

<저서>
1. 약물상호작용의 기전적 이해, 도서출판 신일상사(2005.08.25) ISBN 89-5702-083-7 (93510)
2. 생물약제학과 약동학, 도서출판 신일북스(2013.02.28) ISBN 978-89-5702-349-5
3. 조제학, 도서출판 신일북스(2015.03.20) ISBN 978-89-5702-419-5