이재호

인사말

이재호교수

전문분야 |  1. In vitro 3-dimensional gametogenesis system
2. biophysical cues: nano-electrical stimulation, mechanical stimulation
3. Advanced age infertility therapy
4. in vivo and in vitro direct reprogramming for clincal application

전화번호 | 02-2002-0406
E – mail | jaeho@cha.ac.kr

학력

B.S.(Honors), Dept. of Biotechnology, Taegu University
M.S., Dept. of Microbial Engineering, Kun Kuk University.
Ph.D., Dept. of Biotechnology, Seoul Women’s University
Medical College of Georgia (Post-Doctoral Fellowship)

주요경력

1995 – 1998 Lab of andrology, Infertility Medical center, CHA General Hospital
1998 – 2000 Center for Reproduction & Genetics, BunDang Je-Saeng General Hospital
2000 – 2002 Lab director, Mirae and Heemang OB/Gy Clinic center
2002 – 2004 Lab director, MDplus infertility clinic center
2000 – 2004 Lectur, Molecular Breeding Science, General Biology
2010 – 2013 Full instructor, Dept. Nano Biomedical science, Dankook University
2013 – 2016 Reseach fellow, Nanyang Technological University, MSE.
2016 – present Associate Professor, Dept. of Biomedical Science, CHA University

수상

2016 Springer Nature Award (Seoul)
2005 Promising young scientist award, (ESHRE) 21st Annual meeting (Copenhagen)
2005 Travel grand award, 8th International Congress of Andrology (Seoul)
2001 Young Scientist Award Nominee, ESHRE 17th Annual Meeting (Lausanne)

[Publications]

1. Kyong Hee Choi, Sun Haw Hong, Hye Ran Lee, Hoon Taek Lee*, Jae Ho Lee*, Sang Jin Lee*. Neogenin regulates mitochondrial activity in pre-implantation mouse embryos. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1060-1066.

2. Yan Wang*, Jae Ho Lee*, Hitomi Shirahama, Jeongeun Seo, Jeffrey S. Glenn and Nam-Joon Cho. Extracellular Matrix Functionalization and Huh-7.5 Cell Coculture Promote the Hepatic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells in a 3D ICC Hydrogel Scaffold. ACS Biomater. Sci. Eng., 2016, 2(12): 2255-2265.

3. Mundargi RC, Potroz MG, Park JH, Seo J, Lee JH, Cho NJ. Extraction of sporopollenin exine capsules from sunflower pollen grains. RSC Advances 2016 (6) 16533-16539.

4. Mundargi RC, Potroz MG, Park SH, Park JH, Shirahama H, Lee JH, Seo J, Cho NJ. Lycopodium Spores: A Naturally Manufactured, Superrobust Biomaterial for Drug Delivery. Advanced Functional Materials 2016 (26) 487-497.

5. Mundargi RC, Potroz M, Park JH, Seo JE, Ee-Lin Tan, Lee JH and Cho NJ. Eco-friendly streamlined process for sporopollenin exine capsule extraction. Scientific report 2016 Jan 28;6: 19960

6. Shirahama H, Kumar SK, Jeon WY, Kim MH, Lee JH, Ng SS, Tabaei SR, Cho NJ. Fabrication of Inverted Colloidal Crystal Poly(ethylene glycol) Scaffold: A Three-dimensional Cell Culture Platform for Liver Tissue Engineering. J Vis Exp. 2016 Aug 27;(114).

7. Jae Ho Lee, Yong Il Choi, Sung Sook Choi, Hae-Won Kim, Churl K Min, Sang Jin Lee. a loss- and gain-of-function approach to investigate early cell fate determinants in preimplantation mouse embryos. Journal of Visualized Experiments. 2016 Jun. 6; (112)

8. Kim MH, Kumar SK, Shirahama H, Seo J, Lee JH, Zhdanov VP, Cho NJ. Biofunctionalized hydrogel microscaffolds promote three-dimensional hepatic dheet morphology. Macromolecular Bioscience 2016 Mar;16(3):314-21.

9. Mundargi RC, Potroz M, Park SH, Shirahama H, Lee JH, Seo JE, Cho NJ. Natural sunflower pollen as a drug delivery vehicle. Small. 2016 Mar; 12(9):1167-73.

10. Ing Loon Sean Chua, Hae-Won Kim, Jae Ho Lee. Signaling of extracellular matrices for tissue regeneration and therapeutics. Tissue Engineering and Regenerative Medicine. 2016, Feb Volume 13, Issue 1, 1-12

11. Kim MH, Kumar SK, Shirahama H, Seo J, Lee JH, Cho NJ. Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform. Integr Biol (Camb). 2016 Feb 15; 8(2): 156-166.

12. Jae Ho Lee, Won-Yong Jeon, Hyug-Han Kim, Eun-Jung Lee, Hae-Won Kim. Electrical stimulation by enzymatic biofuel cell to promote proliferation, migration and differentiation of muscle precursor cells. Biomaterials 2015 July 53:358-369

13. Bae Hoon Lee, Myung Hee Kim, Jae Ho Lee, Dror Seliktar, Nam Joon Cho, Lay Poh Tan. Modulation of Huh 7.5 spheroid formation and functionality using modified PEG-based hydrogels of different stiffness. PloS one 2015 Feb 18;10 (2):e0118123.

14. Jae Ho Lee, Ahmed El-Fiqi, Cheol-Min Han, Hae-Won Kim Physically-strengthened collagen bioactive nanocomposite gels for bone: A feasibility study. Tissue Engineering and Regenerative Medicine 2015 January. 12: 1-8.

15. Wojciech Chrzanowski, Jae Ho Lee, Alexey Kondyurin, Megan S. Lord, Jun-Hyeog Jang, Hae-Won Kim, and Marcela M.M. Bilek. Nano-bio-chemical braille for cells – the regulation of stem cell responses using bi-functional surfaces. Advanced functional materials 2015, Jan-14;25(2):193–205

16. Lee Jae Ho, Ja-Yeon Lee, Sung Hee Yang, Eun-Jung Lee, Hae-Won Kim. Carbon nanotube – collagen three-dimensional culture of mesenchymal stem cells promotes expression of neural phenotypes and secretion of neurotrophic factors. Acta Biomaterialia. 2014 Oct; 10(10):4425-36.

17. Jae Ho Lee, Sung Sook Choi, Hae-Won Kim, Wen Cheng Xiong, Churl K. Min, Sang Jin Lee. Neogenin as a receptor for early cell fate determination in preimplantation mouse embryos. PloS One 2014 Jul 11;9(7):e101989.

18. Jin Wan Park, Yun Dan Kang, Jong Soo Kim, Jae Ho Lee,* Hae-Won Kim. 3D microenvironment of collagen hydrogel enhances the release of neurotrophic factors from human umbilical cord blood cells and stimulates the neurite outgrowth of human neuronal precursor cells. Biochemical and Biophysical Research Communications 2014 May 9; 447: 400–406. (*Co-corresponding author)

19. Singh RK, Patel KD, Lee JH, Lee EJ, Kim JH, Kim TH, Kim HW. Potential of magnetic nanofiber scaffolds with mechanical and biological properties applicable for bone regeneration. PLoS One. 2014 Apr 4;9(4):e91584 (SCIE: 1932-6203)

20. Lee JH, Park JH, El-Fiqi A, Kim JH, Yun YR, Jang JH, Han CM, Lee EJ, Kim HW. Biointerface control of electrospun fiber scaffolds for bone regeneration: Engineered protein link to mineralized surface. Acta Biomaterialia. 2014 Jun 10(6):2750-61.

21. Perez R, Kim M, Kim TH, Kim JH, Lee JH, Park JH, Knowles JC, Kim HW. Utilizing core-shell fibrous collagen-alginate hydrogel cell delivery system for bone tissue engineering. Tissue Eng Part A. 2014 Jan; 20(1-2):103-114.

22. Jae Ho Lee, Jeong-Hui Park, Mohamed Eltohamy, Roman Perez, Eun-Jung Lee and Hae-Won Kim. Collagen gel combined with mesoporous nanoparticles loading nerve growth factor as a feasible therapeutic three-dimensional depot for neural tissue engineering. RSC Advances 2013(Jul); 3:24202–24214

23. El-Fiqi A, Lee JH, Lee EJ, Kim HW Collagen hydrogels incorporated with surface-aminated mesoporous nanobioactive glass: improvement of physicochemical stability and mechanical properties effective for hard tissue engineering. Acta Biomaterialia. 2013 Dec; 9(12):9508-95021

24. Hyung-seok Park, Myoung-Seon Gong, Ivan wall, Hae-Won Kim, Jae Ho Lee*, Jonathan C*. Knowles. Silk fibroin-polyurethane blends: physical properties and effect of silk fibroin content on biocompatibility and myoblast differentiation. Acta Biomaterialia. 2013 Nov; 9(11):8962-71.(*Co-corresponding author)

25. Jae Ho Lee, Jeong-Hui Park, Ye-Rang Yoon, Jun-Hyeog Jang, Eung-Jung Lee, Wojciech Chranowski, Ivan Wall and Hae-Won Kim. Tethering bi-functional protein onto mineralized polymer scaffolds to regulate mesenchymal stem cell behaviors for bone regeneration. RSC Journal of Materials Chemistry B. 2013; 1(21); 2731-41.

26. Chrzanowski W, Kondyurin A, Lee JH, Lord MS, Bilek MM, Kim HW. Biointerface protein enhanced stem cells binding to implant surfaces for improved osteointegration. Journal of Materials Science: Materials in Medicine, 2012 Sep; 23(9):2203-15.

27. Sun Ae Oh, Hye Young Lee, Jae Ho Lee, Tae Hyun Kim, Jun Hyeog Jang; Hae Won Kim, Ivan Wall. Collagen three dimensional hydrogel matrix carrying basic fibroblast growth factor for the cultivation of mesenchymal stem cells and osteogenic differentiation. Tissue engineering. Part A 2012 Jan. 18(9~10):1087-1100.

28. Jae Ho Lee, Hye-Young Lee, Hae-Won Kim. Adhesive proteins linked with focal adhesion kinase regulate neurite outgrowth of PC12 cells. Acta Biomaterialia. 2012 Jan, 8(1):165–172