정광회

인사말

정광회 교수

혈전 생화학
Studies on the fibrinolytic enzymes from the venom of Agkistrodon halys

전화번호 | 031-881-7017
Email | hoe@cha.ac.kr

​학력

연세대학교 생화학과 (이학사)
연세대학교 생화학과 대학원 (이학석사)
연세대학교 생화학과 대학원 (이학박사)

주요경력

1984 – 1996 : (재)목암생명공학연구소 수석연구원/생물화공연구부장
1990 – 1991 : 영국 Cortecs Research Inst. 객원연구원
1997 – 2006 : 연세대학교 의과대학 의과학과 대학원 및 심혈관연구소 부교수 역임
1997 – 현재 : 지식경제부 바이오분야 기획 및 평가위원
1998 – 2009 : 한국혈전지혈학회 학술이사, 총무이사
2000 – 2006 : 주식회사 바이오버드 대표이사 겸 연구소장
2001 – 2006 : 연세프로테옴연구센터(YPRC) 기획위원장
2001 – 2003 : 한국프로테옴기구(HUPO) 재무위원장
2002 – 2002 : 제2차 아시아태평양 혈전지혈학술대회(서울) 학술위원장
2002 – 2007 : 국가지정연구실(심혈관치료연구실)실장
2004 – 2007 : 한국바이오벤처협회 이사
2005 – 2006 : 캐나다 University of Toronto 방문교수
2006 – 2009 : 차 의과학대학교 의생명과학과 부교수
2009 – 2012 : 한국혈전지혈학회 이사장
2012 – 현재: 한국혈전지혈학회 부회장
2010 – 2012 : 차 의과학대학과 바이오공학과 주임교수/학과장
2011 – 2012 : 차 의과학대학교 연구처장 겸 산학협력단장
2012 – 2013: (주)차바이오메드 대표이사
2012 – 현재: 차 의과학대학교 기획처장/ 바이오공학과 교수

 

주요연구내용
– 혈전과 암의 상호작용 및 억제연구
– 프로테오믹스를 이용한 난치성질환 마커발굴 및 실용화연구
– 혈관내피세포와 평활근세포의 증식 조절 연구
– 유전자재조합 단백질의 산업화 연구
– 자가 줄기세포 및 혈액세포 분리시스템의 산업화

국외논문(최근5년간)

1. Chung HJ, Jung OJ, Chae MJ, Hong SY, Chung KH, Lee SK, Ryu CK (2005) Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation. Bioorganic & Medicinal Chem. Lett. 15, 3380-4.

2. Do HJ, Song KS, Kang MS, Kim DS, Kim KA, Kang J, Jang Y, Chung KH (2005) A Novel monoclonal antibody that recognizes new neoantigenic determinant of D-dimer. Thromb. Res. 118, 353-60.

3. You WK, Jang YJ, Chung KH, Jeon OH, Kim DS (2006) Functional roles of the two distinct domains of halysase, a snake venom metalloprotease, to inhibit human platelet aggregation. Biochem Biophys Res Commun. 339, 964-70.
4. Kim KS, Kim DS, Chung KH, Park YS (2006) Inhibition of angiogenesis and tumor progression by hydrodynamic cotransfection of angiostatin K1-3, endostatin, and saxatilin genes. Cancer Gene Therapy 13, 563-71.

5. Song KS, Park NJ, Choi JR, Doh HJ, Chung KH (2006) Fibrinogen Seoul(FGG Ala341Asp): a novel mutation associated with hypodysfibrinogenemia. Clin. Appl. Thromb. Hemost. 12, 338-43.

6. Park R, Doh HJ, An SS, Choi JR, Chung KH, Song KS (2006) A novel fibrinogen variant (fibrinogen Seoul II; A alpha Gln328Pro) characterized by impaired fibrin alpha-chain cross-linking. Blood 108, 1919-24.

7. Chung KH, Hong SY, You HJ, Park RE, Ryu CK (2006) Bioorganic & Medicinal Chem. 14, 5795-801.

8. Kim DW, Kim SY, An JJ, Lee SH, Jang SH, Won MH, Kang TC, Chung KH, Jung HH, Cho SW, Choi JH, Park JS, Eum WS, Choi SY. (2006) Expression, Purification and Transduction of PEP-1-Botulinum Neurotoxin Type A (PEP-1-BoNT/A) into Skin. J. Biochem. Mol. Biol. 39, 642-7.

9. Hong SY, Kwak KW, Kang SJ, Ryu CK, Chung KH. (2008) Antiproliferative effects of 6-anilino-5-chloro-1H-benzo[d]imidazole-4,7-dione in vascular smooth muscle cells. Bioorganic & Medicinal Chemistry. 16, 644-649.

10. Sohn YD, Hong SY, Cho KS, Choi WS, Song SW, Bae JS, Kim DS, Chung KH. (2008) Acute and repeated dose toxicity studies of recombinant saxatilin, a disintegrin from the Korean snake (Gloydius saxatilis). Toxicon 51, 406-417.

11. Sohn YD, Cho KS, Sun SA, Sung HJ, Kwank KW, Hong SY, Kim DS, Chung KH (2008) Suppressive effect and mechanism of saxatilin, a disintegrin from Korean snake (Gloydius saxatilis) in vascular smooth muscle cells. Toxicon 52, 474-480.

12. Ryu CK, Lee RY, Lee SY, Chung HJ, Lee SK, Chung KH (2008) Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors. Bioorg. Med. Chem Lett. 18, 2948-51

13. Chung KH, Lee DH, Kim Y, Kim TH, Huh JH, Chung SG, Lee S, Lee C, Ko JJ, An HJ (2010) Proteomic identification of overexpressed PRDX 1 and its clinical implications in ovarian carcinoma. J. Proteome Res. 9, 451-7.

14. Min CK, LEE JW, Chung KH, Park HW (2010) Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant Pichia pastoris. J. Biosci. Bioeng. 110. 314-9.

97. Hye-Cheol Jeong, Gwang-Il Kim, Sang-Ho Cho, Kwang-Hyung Lee, Jung-Jae Ko, Jeong-Hee Yang, Kwang-Hoe Chung(2010) Proteomic Analysis of Human Small Cell Lung Cancer Tissues: Up-regulation of Coactosin-Like Protein-1. J. Proteome Res. 10, 269-276.

98. . Seo MJ, Choi HJ, Chung KH, Pyun YR (2011) Production of a platelet aggregation inhibitor, salmosin, by high cell density fermentation of recombinant Escherichia coli. J. Microbiol. Biotechnol. 21, 1053-6.

99. Hong-Bum Park, Jeong-Hee Yang, Kwang-Hoe Chung (2011) Characterization and the cytokine profile of platelet-rich plasma and PRP-induced cell proliferation and migration. Kor. J. Hematol.46(4),265-274.

100. Min PK, Kim JY, Chung KH, Lee BK, Cho M, Lee DL, Hong SY, Choi EY, Yoon YW, Hong BK, Rim SJ, Kwon HM (2013) Local increase in microparticles from the aspirate of culprit coronary arteries in patients with ST-segment elevation myocardial infarction. Atherosclerosis 227(2) April 323-328.

101. Kwang-Hyoung Lee, Kyoung-Soo Ha, Sung-Hoon Jo, Chong M. Lee,
Young-Cheul Kim, Kwang-Hoe Chung,* Young-In Kwon (* Co-coressponding authors). (2014) Effect of Long-Term Dietary Arginyl-Fructose (AF) on Hyperglycemia and HbA1c in Diabetic db/db Mice. Int. J. Mol. Sci., 15, 8352-8359.

102. Park SE, Kim OH, Kwak JH, Lee KH, Kwon YI, Chung KH*, Lee JH* (* Co-coressponding authors). (2015) Antihyperglycemic effect of short-term arginyl-fructose supplementation in subjects with prediabetes and newly diagnosed type 2 diabetes: randomized, double-blinded, placebo-controlled trial. Trials, 2015, 16, 521-529.

103. Kim OH, Cho KS, Seomun Y, Kim JT, Chung KH. (2017) Acute and repeated dose (28 days) toxicity studies in rats and dogs of recombinant batroxobin, a snake venom thrombin-like enzyme expressed from Pichia pastoris. Toxicon 129, 153-163.

104. Kim AR, PArk TJ, Kim MS, Kim IH, Kim KS, Chung KH, Ko S. (2017) Functional fusion proteins and prevention of electrode fouling for a sensitive electrochemical immunosensor. Anal. Chim. Acta 967, 70-77.

특허출원/등록

– 국내 40건, 국제특허 15건

 

산업화 실적
– 지방줄기세포 추출장치 CHA-STATION 출시 (차바이오메드, 20개국 수출)
– 유전자재조합 인터페론 알파 (녹십자 판매)
– 유전자재조합 B형 간염백신 HepaVax-gene (녹십자 판매)
– 국내 최최의 심혈관예방식품 Thrombo-Q (풀무원 판매)

 

수상경력
– 2000년도 연세의대 우수교수상 (연구부문)
– Top 100 Scientists of Year 2005 (심혈관연구분야)(영국 국제인명록협회)