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Yong-Soo Choi

Yong-Soo Choi

전공Biopharmaceutical, Animal Cell Culture Engineering
연락처 031-881-7125 yschoi@cha.ac.kr
연구실 홈페이지 http://tre.cha.ac.kr/

학력

  • 인하대학교 대학원 생물공학 박사
  • 인하대학교 대학원 생물공학 석사
  • 인하대학교 생물공학 학사

경력

  • 2016 – 현 재 : 바이오공학과, 부교수
  • 2019 – 2020 : 바이오공학과, 학과장
  • 2014 – 2015 : 차바이오텍, 줄기세포연구소, 소장
  • 2013 – 2014 : 차바이오텍, GMP연구단, 단장
  • 2013 – 2015 : 분당차병원, GMP운영단, 단장
  • 2011 – 2013 : 차바이오텍, 세포 및 조직공학연구소, 소장
  • 2009 – 2015 : 차의과학대학교, 바이오공학과, 조교수
  • 2005 : University of Minnesota, Stem Cell Institute 연수


    • [실험실]
  • Mitochondrial Engineering Laboratory (MELab)


    • [특허]
  • 미토콘드리아를 포함하는 허혈성 질환 예방 또는 치료용 조성물(기술이전)
  • 미토콘드리아를 포함하는 근질환 예장 또는 치료용 약학 조성물(기술이전)
  • 개질된 미토콘드리아 및 이의 용도
  • 분리된 미토콘드리아를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물(기술이전)
  • 외래 미토콘드리아를 세포로 전달하는 방법(기술이전)
  • 세포 배양용 지지체, 이의 제조 방법 및 이를 이용한 세포 배양 방법(기술이전)
  • 미토콘드리아를 포함하는 약학 조성물(기술이전)
  • 분리된 미토콘드리아를 유효성문으로 포함하는 탈모 예방 및 발모 촉진용 약학 조성물
  • 지방흡입 유출물로부터 초임계공정을 이용하여 콜라겐을 분리하는 방법
  • 미토콘드리아를 포함하는 허혈성 질환 예방 또는 치료용 조성물(기술이전)
  • 포유류 탯줄 유래 줄기세포 배양액을 유효성분으로 포함하는 근위축증의 예방 또는 치료용 약제학적 조성물
  • 누에 혈림프 유래 70KDa 단백질을 포함하는 화장료 조성물(기술이전)
  • 누에 혈림프 유래 단백질 및 그의 용도
  • 인간 제대혈 유래 내피 전구세포의 배양방법 및 인간 제대혈 유래 내피 전구세포를 포함하는 허혈성 질환의 예방 또는 치료용 조성물
  • 탯줄 유래 줄기세포를 포함하는 근위축 질환 개선 또는 치료용 조성물
  • 누에실샘 유래 가수분해물을 포함하는 화장료 조성물
  • 콜라겐 및 히알루론산 유도체를 포함하는 의료용 복합 생체 소재(기술이전)
  • 콜라겐, 히알루론산 유도체 및 포유류의 탯줄 유래 줄기세포를 포함하는 연골세포치료제(기술이전)
  • 탯줄 추출물의 제조방법 및 그의 용도(기술이전)
  • 누에 실샘 유래 가수분해물을 이용한 의료용 드레싱재 및 그 제조방밥
  • 누에 실샘 유래 가수분해물의 수득방법
  • 누에 혈림프 유래 단백질의 대량 정제방법 및 이를 통해 정제된 단백질
  • 누에 실샘 초미세분말 유래 수용성 세리신을 포함하는 화장료 조성물
  • 포유류의 탯줄 유래 줄기세포 분리 또는 배양용 배지 조성물, 그리고 이를 이용한 포유류의 탯줄 유래 줄기세포 분리 또는 배양방법(기술이전)

논문

    [주요연구내용]
  • Mitochondrial Therapy
  • Stem Cells Therapy


    • [논문]
  • Umbilical cord mesenchymal stem cell-conditioned medium improves insulin resistance in C2C12 cell Kim KS, Choi YK, Kim MJ, Hwang JW, Min K, Jung SY, Kim SK, Choi YS*, Cho YW. Diabetes Metab. J., 2020, Accepted. (IF 3.263)
  • CRH receptor antagonists from Pulsatilla chinensis prevent CRH-induced premature catagen transition in human hair follicles Nam YJ, Lee, EY, Choi EJ, Kang S, Kim J, Choi YS, Kim DH, An JH, Han I, Lee S, Lee MH, Kim YH, Chung JH. J Cosmetic Dermatol, 2020, (DOI: 10.1111/jocd.13328). (IF 1.311) PubMed Web PDF
  • Hair growth-promoting effect of recombinant human sonic hedgehog proteins Yu SH, K Y, Jung N, Hwang JW, Kim N, Ha JC, Kim MJ, Lee Y, Choi YS, Han K, Kim CH. Biomed Dermatol, 2019, 3: 7. Web PDF
  • The restoration of cellular proliferation and characteristics of human tenocytes by vitamin D Min KH, Lee JM, Kim MJ, Jung SY, Kim KS, Lee SC, Choi YS*. J. Orthop. Res., 2019, 37(10). (IF 3.414) PubMed Web PDF
  • Nanoinjection system for precise direct delivery of biomolecules into single cells (Featured Cover Article) Yun CK, Hwang JW, Kwak TJ, Chang WJ, Ha SJ, Han KB, Lee SH, Choi YS*. Lab Chip, 2019, 19:580-588. (IF 6.914) PubMed Web PDF
  • Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function Kim MJ, Hwang JW, Yun CK, Lee YJ, Choi YS*. Sci. Rep., 2018, 8:3330. (IF 4.259) PubMed Web PDF
  • Efficient cryopreservation of human mesenchymal stem cells using silkworm hemolymph-derived proteins Kim SM, Yun CK, Park JH, Hwang JW, Kim ZH, Choi YS*. J Tissue Eng Regen Med., 2017, 11:8;2181–2192. (IF 5.199) Web PDF
  • The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable response Han YM, Park JM, Choi YS, Jin H, Lee YS, Han NY, Lee H, Hahm KB. Stem Cell Res Ther., 2017, 2;8(1). (IF 4.211) PubMed Web PDF
  • Evaluation of the wound-healing activity of rice cell extracts in vitro Kim ZH, Kim SM, Park JH, Park CM, Choi HY, Lee H, Park JK, Kwon S, Kim DI, Chang KH, Choi YS*, Lim SM. Microbiol Biotechnol Lett., 2016, 44(3). Web PDF
  • Conditioned medium derived from umbilical cord mesenchymal stem cells regenerates atrophied muscles (Featured Cover Article) Kim MJ, Kim ZH, Kim SM, Choi YS*. Tissue Cell., 2016, 48(5):533-43. (IF 1.258) PubMed Web PDF
  • Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice Byun SH, Lee JH, Jung NC, Choi HJ, Song JY, Han H, Choi J, Jung SY, Kang S, Choi YS, Chung JH, Lim DS. Biochem Pharmacol., 2016, 115: 85-93.. (IF 5.01) PubMed Web
  • Effects of storage-protein 2 derived from silkworm hemolymph on reduction of aggregation and cell death in CHO cells Lim JH, Cha HM, Kim Z, Choi YS, Kim DI. Korean J Biotechnol Bioeng., 2016, 31(1): 66-72. Web PDF
  • Umbilical cord mesenchymal stem cell-conditioned media prevent muscle atrophy by suppressing muscle atrophy-related proteins and ROS generation Park CM, Kim MJ, Kim SM, Park JH, Kim ZH, Choi YS*. In Vitro Cell Dev Biol Anim., 2015, 52(1):68-76. (IF 1.145) PubMed Web PDF
  • Scaffold-free Three-dimensional culture systems for mass production of periosteum-derived progenitor cells Cha HM, Kim SM, Choi YS, Kim DI. J Biosci Bioeng., 2015, 120(2), 218-222. (IF 1.869) PubMed Web PDF
  • A Composite Dermal Filler Comprising Cross-Linked Hyaluronic Acid and Human Collagen for Tissue Reconstruction Kim ZH, Lee YJ, Kim SM, Kim HJ, Yun CK, and Choi YS*. J Microbiol Biotechnol., 2015, 25(3), 399–406. (IF 1.32) PubMed PDF
  • Serum-free Media supplement from Silkworm gland for the expansion of mesenchymal stem cells Cha HM, Kim SM, Choi YS*, Par JS, Lim JH, Hwang SG, Kim DI. Tissue Eng Regen Med., 2015, 12(s1): 53-59. (IF 0.613) Web PDF
  • Sensitive and selective analysis of a wide concentration range ofIGFBP7 using a surface plasmon resonance biosensor Jang DH, Choi YB, Choi YS, Kim SM, Kwak HJ, Shin SH, Hong SR. Colloids and Surfaces B: Biointerfaces., 2014, 123:887-891. (IF 4.287) Web PDF
  • Short-term effects of etythropoietin on neurodevelopment in infants with cerebral palsy: A pilot study Lee HS, Song J, Min K, Choi YS, Kim SM, Cho SR, Kim MY. Brain Dev., 2014, 36(9): 764-769. (IF 1.668) Web PDF
  • Whitening effect of storage protein 2 from silkworm hemolymph Kim ZH, Hwang JW, Lee JH, Kim H, Lim DS, Kang S, Lee HS, Choi YS*. Adv Biosci Biotechnol., 2014, 5: 758-767. Web PDF
  • Transplantation of Insulin-Producing Cells Differentiated from Human Periosteum-Derived Progenitor Cells Ameliorate Hyperglycemia in Diabetic Mice Dao LTM, Park EY, Lim SM, Choi YS, Jun HS. Transplantation., 2014, 98: 1040-1047. (IF 3.781) PubMed PDF
  • Wound healing properties of a 3-D scaffold comprising soluble silkworm gland hydrolysate and human collagen Kim KO, Lee Y, Hwang JW, Kim H, Lee HS, Choi YS*. Colloids Surf. B: Biointerfaces., 2014, 116: 318-326. (IF 4.287) PubMed Web PDF
  • Pancreatic islet-like clusters from periosteum-derived progenitor cells Kim SJ, Choi YS*. Kim SM, Lim SM, Park EY, Hwang OK, Jun HS, Lee CW, Kim DI. Biotechnol Bioprocess Eng., 2013, 18(6): 1116-1121. (IF 1.277) Web PDF
  • Alternative xeno-free biomaterials derived from human umbilical cord for the self-renewal ex-vivo expansion of mesenchymal stem cells Kim SM, Moon SH, Lee Y, Kim GJ, Chung HM, Choi YS*. Stem Cells Dev., 2013, 22(22): 3025-3038. (IF 4.67) PubMed Web PDF
  • Development of a xeno-free autologous culture system for endothelial progenitor cells derived from human umbilical cord blood Moon SH, Kim SM, Park SJ, Kim H, Bae D, Choi YS*, Chung HM. PLos One., 2013, 8(9): 1-10. (IF 3.73) PubMed Web PDF
  • Whitening and anti-aging activities of soluble silkworm gland hydrolysate Jung JH, Hwang JW, Kim H, Cha HM, Kim DI, Choi YS*. Korean J Biotechnol Bioeng., 2013, 28(3): 196-201. Web PDF
  • Effects of Silkworm Gland Hydrolysate on Albumin-erythropoietin Production in Transgenic Chinese Hamster Ovary Cells Choi MH, Cha HM, Kim SM, Choi YS, Kim DI. Korean J Biotechnol Bioeng., 2013, 28(2): 86-91. Web PDF
  • Anti-oxidant and anti-aging activities of Sericinjam gland hydrolysate extract in human dermal fibroblasts Cheon Y, Hwang JW, Lee HS, Yun S, Choi YS, Kang S. J Soc Cosmet., 2013, 39(1): 9-17. Web PDF
  • Manufacture and characterization of silkworm gland hydrolysate Hwang JW, Lee HS, Kim HJ, Kim KO, Choi YS*. J Seric Entomol Sci., 2012, 50(2): 76-81. Web PDF
  • Human Placenta Extract Could Promote Proliferating Cell Nuclear Antigen Expression during Liver Regeneration Induced by Partial Hepatectomy in Rats Kim JH, Han K, Choi YS, Lee YJ, Yoon KH, Han MD, Kim WJ. Applied Microscopy., 2012, 42(3): 115-123. Web PDF
  • Glucose-stimulated insulin secretion of various mesenchymal stem cells after insulin-producing cell differentiation Kim SJ, Choi YS, Ko ES, Lim SM, Lee CW, Kim DI. J Biosci Bioeng., 2012, 113(6): 771-777. (IF 1.737) PubMed PDF
  • Effects of mixed feeder cells on the expansion of CD34+ cells Choi YS, Lim DS, Lim SM, Kim DI. J Biosci Bioeng., 2012, 113(3): 389-394. (IF 1.737) PubMed PDF
  • Mesenchymal stem cell-mediated immature dendritic cells induce regulatory T cell-based immunosuppressive effect Choi YS, Jeong JA, Lim DS. Immunol Invest., 2012, 41: 214-229. (IF 1.731) PubMed
  • Optimization of ex vivo hematopoietic stem cell expansion in intermittent dynamic cultures Choi YS, Noh SE, Lim SM, Kim DI. Biotechnol Lett., 2010, 32: 1969-1975. (IF 1.853) PubMed PDF

저서/역서/편서