암의 진단을 위한 바이오마커 발굴과 생식세포 연구를 통한 난임치료, 난치병의 치료를 위해 줄기세포에 관한 기초연구와 기능성식품의 응용 가능성에 대해 연구를 진행하고 있으며, 구체적인 연구는 아래와 같다.
각종 암관련 바이오 마커의 발굴을 통한 진단용 kit의 개발
기능성식품을 이용한 임상응용 가능성 연구
생식세포관련 기초연구 및 임상실험
1. Kim KH, Kim EY, Lee SY, Ko JJ, Lee KA. Oocyte Cytoplasmic Gas6 and Heparan Sulfate (HS) Are Required to Establish the Open Chromatin State in Nuclei During Remodeling and Reprogramming. 2018. Celluler Physiology and Biochemistry, 2018, 45:37-53. (IF: 5.104)
2. Yoon HM, Jang H, Kim EY, Moon SH, Lee SH, Cho MH, Cho HJ, Ko JJ, Chang MC, Lee KA, Choi YS. Knockdown of PRKAR2B Results in the Failure of Oocyte Maturation. Cellular Physiology and Biochemistry 2018.45:2009-2020. (IF: 5.104)
3. Choi JH, Ji YG, Ko JJ, Cho HJ, Lee DH. Activating P2X7 Receptors increases proliferation of human pancreatic cancer cells via ERK1/2 and JNK. 2018. Mar.(IF:2.967)
4. Cho SH, Kim YR, Kim JH, An HJ, Kim JO, Ko JJ, Lee WS, Kim NK. The association of miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T polymorphisms with a risk of primary ovarian insufficiency in Korean women. 2018. Menopause 26(4) 409-416.
5. Kim KH, Kim EY, Ko JJ, Lee KA. Gas6 is reciprocal regulator of mitophagy during mammalian oocyte maturation. Scientific Reports. 2019. 9:10343.
6. Kim MJ, Choi KH, Seo DW, Lee HR, Kong HS, Lee CH, Lee WS, Lee HT, Ko JJ, Kim JH, Lee SJ, Lee JH. Association Between Functional Activity of Mitochondria and Actin cytoskeleton Instability in oocytes from Advanced Age Mice. Reproductive Sciences. 2020. 27:1037-1046.
7. Lee CJ, Hong SH, Yoon MJ, Lee KA, Ko JJ, Koo HS, Kim JH, Choi DH, Kwon H, Kang YJ. Endometrial Profilin 1: A key player in embryo endometrial crosstalk. Clin Exp Reprod Med. 2020. 47(2):114-121.
8. lee CJ, Hong SH, Yoon MJ, Lee KA, Choi DH, Kwon H, Ko JJ, Koo HS, Kang YJ. Eupatilin treatment inhibits TGF beta-induced endometrial fibrosis in vitro. 2020. 47(2):108-113.
9. Shin TE, Park JW, Jeon WY, Lee EJ, Kwon HJ, Jeon BY, Kang HE, Kim MJ, Kim DK, Kim HH, Ko JJ, Lee JH. Motility enhancement of human spermatozoa using electrical stimulation in the nano-Ampere range with enzymatic biofuel cells. 2020. PloS ONE 15(2):e0228097.
10. Kim KH, Kim EY, Kim GJ, Ko JJ, Cha KY, K MK, Lee KA. Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats. Stem Cell Research & Therapy. 2020. 11:472.
11. Yu WD, Kim YJ, Cho MJ, Seok J, Kim GJ, Lee CH, Ko JJ, Kim YS, Lee JH. The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro. Mitochondrion 58(2021)135-146.
12. Kim YJ, Park YJ, Park YR, Kim YS Lee HR, Lee SJ, Kim MJ, Kwack KB, Ko JJ, Lee JH. Role of RGMc as a Neogenin Ligand in Follicular Development in the Ovary. Biomedicines 2021, 9, 280
13. Koo SK, Yoon MJ, Hong SH, Ahn JA, Cha HJ, Lee DB, Ko JE, Kwon H, Choi DH, Lee KA, Ko JJ, Kang YJ. CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice. Scientific reports 2021 11:7397
14. Yu WD, Kim YJ, Cho MJ, Kim GJ, Kim SH, Kim MJ, Ko JJ, Lee JH. MIT-001 Restore Human Placenta-Derived Mesenchymal Stem Cells by Enhancing Mitochodrial Quiescence and Cytoskeletal Organizaation. Molecular Sciences 2021, 22,5062.
15. Cho SH, Kim JH, An HJ, Kim YR, Ahn EH, Lee JR, Kim JO, Ko JJ, Kim NK. Genetic Polymorphisms in miR-604A>G, miR-938G>A, miR-1302-3C>T and the Risk of Idiopathic Recurrent Pregnancy Loss. Molecular Sciences 2021, 22, 6127.
16. Kim MJ, Kim YS, Kim YJ, Lee HR, Choi KH, Park EA, Kang KY, Yoon TK, Hwang SH, Ko JJ, Kim YS, Lee JH. Upregulation of Low-density lipoprotein receptor of the steroidogenesis pathway in the cumulus cells is associated with the maturation of oocytes and achievement of pregnancy. Cells 2021, 10, 2389.
17. Lee MH, park JW, Kim DW, Kwon HJ, Cho MJ, Lee EJ, Shin TE, Kim DK, Lee SK, Byeun DG, Ko JJ, Choi JK. Viscous Cervical Environment-on-a-Chip for Selecting High-Quality Sperm from Human Semen. Biomedicines 2021, 9, 1439.
18. Oqani RK, So SJ, Lee YM, Ko JJ, Kang EJ. Artificial Oocyte: Development and potential application. Cells 2022, 11, 1135.
19. Lee YM, Kim M C, Lee MJ, So AJ, Kang SS, Choi JW, Kim DH, Heo HH, Lee SS, Park HR, Ko JJ, Song JW, Kang EJ. Mitochondrial genome mutations and neuronal dysfunction of induced pluripotent stem cells derived from patients with Alzheimer's disease. Cell Prolif. 2022;e13274.