2018-2022: University of North Carolina at Chapel Hill, 박사후연구원
본 연구실은 Polymer 혹은 Lipid를 기반으로 하는 약물전달시스템을 개발하는 연구를 주로 진행하고 있습니다. Chemical drug 뿐만 아니라 gene materials 및 protein/peptide delivery 쪽으로도 다양한 연구를 진행합니다.
C. Lim 1, D. Hwang 1, Y. Mostafa, J.D. Ramsey, G. Dotti, Sokolsky, A.V. Kabanov, High-Dose Paclitaxel and its Combination with CSF1R Inhibitor in Polymeric Micelles for Chemoimmunotherapy of Triple Negative Breast Cancer, Nano Today, 51 (2023), 101884 (Impact factor: 18.9).
P. Husni, Y. Shin, H Jeon, E.S. Lee, Y.S. Youn, C.D. Poon, C. Lim *, K.T. Oh * (Corresponding author), Development and characterization of pH-responsive nanocarriers for chemo-photothermal combination therapy in glioblastoma treatment, Journal of Controlled Release, 359 (2023), 52 (Impact factor: 11.5).
Y Shin, M Kim, C. Lim *, K.T. Oh *, (Corresponding author) RNA-Seq-guided triple-combination nano-system of gold nanocluster, quercetin, and docetaxel for ultimate synergistic photothermal-chemotherapy against MDR tumor, Nano Today, 50 (2023), 101862. (Impact factor: 18.9).
P. Husni, C. Lim *, K.T. Oh * (Corresponding author), Tumor microenvironment stimuli-responsive lipid-drug conjugates (LDCs) for cancer treatment, International Journal of Pharmaceutics, (2023), 122942.
C. Lim 1, Y. Shin 1, K. Kang, P. Husni, D. Lee, S. Lee, H. Choi, E.S. Lee, Y.S. Youn, K.T. Oh, Effects of PEG-Linker Chain Length of Folate-Linked Liposomal Formulations on Targeting Ability and Antitumor Activity of Encapsulated Drug, International Journal of Nanomedicine, (2023), 1615.
C. Lim 1, D. Lee1, M. Kim, S. Lee, Y. Shin, J. D. Ramsey, H. Choi, E.S. Lee, Y.S. Youn, K.T. Oh, Development of a sorafenib-loaded solid self-nanoemulsifying drug delivery system: Formulation optimization and characterization of enhanced properties, Journal of Drug Delivery Science and Technology, 82 (2023), 104374.
C Lim, J Koo, K.T. Oh, Nanomedicine approaches for medulloblastoma therapy, Journal of Pharmaceutical Investigation, 10 (2022), 00597.
C Lim, Y Shin, S Lee, S Lee, M Lee, B Shin, K.T. Oh, Dynamic drug release state and PEG length in PEGylated liposomal formulations define the distribution and pharmacological performance of drug, Journal of Drug Delivery Science and Technology, 9 (2022), 103825.
C. Lim 1, T. Dismuke 1, D. Malawsky, J.D. Ramsey, D. Hwang, V.L. Godfrey, A.V. Kananov, T.R. Gershon, M. Sokolsky, Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib, Science advances, 8 (2022) eabl5838 (Impact factor: 14.9).
C. Lim, J.D. Ramsey, D. Hwang, S. Teixeira, C.D. Poon, J.D. Strauss, M. Sokolsky, A.V. Kabanov, Drug-dependent morphological transitions in spherical and worm-like micelles define stability and pharmacological performance of micellar drugs, Small, 18 (2022), 2103552 (Impact factor: 15.1).
C. Lim, J.K. Kang, C.E. Jung, T. Sim, J. Her, K. Kang, E.S. Lee, Y.S. Youn, H.-G. Choi, K.T. Oh, Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability, AAPS PharmSciTech, 22 (2021) 169.
T. Sim1, C. Lim, N.H. Hoang, Y. Shin, J.C. Kim, J.Y. Park, J. Her, E.S. Lee, Y.S. Youn, K.T. Oh, An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy, Pharmaceutics. 12 (9) (2020) 839.
C. Lim, W.R. Won, J. Moon, T. Sim, Y. Shin, J.C. Kim, E.S. Lee, Y.S. Youn, K.T. Oh, Co-delivery of d-(KLAKLAK)2 peptide and doxorubicin using a pH-sensitive nanocarrier for synergistic anticancer treatment, Journal of Materials Chemistry B, 7 (2019) 4299-4308.
C. Lim, J. Moon, T. Sim, W.R. Won, E.S. Lee, Y.S. Youn, K.T. Oh, A nano-complex system to overcome antagonistic photo-chemo combination cancer therapy, Journal of Controlled Release, 295 (2019) 164-173 (Impact factor: 11.5).
C. Lim, J.K. Kang, W.R. Won, J.Y. Park, S.M. Han, T.N. Le, J.C. Kim, J. Her, Y. Shin, K.T. Oh, Co-delivery of D-(KLAKLAK)(2) Peptide and Chlorin e6 using a Liposomal Complex for Synergistic Cancer Therapy, Pharmaceutics, 11 (2019) 293.