차 의과학대학교CHA University
 
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최용수

최용수 교수

전공바이오의약품학
연락처 031-881-7125 yschoi@cha.ac.kr

학력

    인하대학교 대학원 생물공학 박사 인하대학교 대학원 생물공학 석사 인하대학교 생물공학 학사

경력

  • 2016 – 현 재 : 바이오공학과, 부교수
  • 2019 – 2020 : 바이오공학과, 학과장
  • 2014 – 2015 : 차바이오텍, 줄기세포연구소, 소장
  • 2013 – 2014 : 차바이오텍, GMP연구단, 단장
  • 2013 – 2015 : 분당차병원, GMP운영단, 단장
  • 2011 – 2013 : 차바이오텍, 세포 및 조직공학연구소, 소장
  • 2009 – 2015 : 차의과학대학교, 바이오공학과, 조교수
  • 2005 : University of Minnesota, Stem Cell Institute 연수


논문

  • Laboratory: http://mito.cha.ac.kr
  • Mitochondrial Engineering Laboratory (MELab)

  • Research Fields
  • Mitochondrial Transplantation Therapy
  • Stem Cells Therapy

    • [국내외 논문(최근)]
  • Xenogeneic transplantation of mitochondria induces muscle regeneration in an in vivo rat model of dexamethasone-induced atrophy
  • Kim MJ, Lee JM, Min K, Choi YS*., J Muscle Res Cell Motil., 2023, https://doi.org/10.1007/s10974-023-09643-7.
  • Paraspinal muscles atrophy on both sides and at multiple levels after unilateral lumbar partial discectomy
  • Lee D, Cha B, Kim J, Choi YS, Kim MY, Han I, Min KH., Medicine, 2022, 102(3): e32688.
  • Gossypol Induces Apoptosis of Human Pancreatic Cancer Cells via CHOP/Endoplasmic Reticulum Stress Signaling Pathway
  • Lee S, Hong E, Jo E, Kim ZH, Yim KJ, Woo SH, Choi YS, Jang HJ., J. Microbiol. Biotechnol., 2022, 32(5): 645-656.
  • Ex vivo expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells through different receptor-ligand interactions
  • Jung D, Baek YS, Lee I, Kim KY, Jang H, Hwang S, Jung J, Moon Y, Park YS, Choi YS, Ahn HJ., J. Exp. Clin. Cancer Res., 2021, 40: 333.
  • Mitochondrial Transplantation Modulates Inflammation and Apoptosis, Alleviating Tendinopathy both in vivo and in vitro
  • Lee JM, Hwang JW, Kim MJ, Jung SY, Kim KS, Ahn EH, Min KH*, Choi YS*., Antioxidants, 2021, 10(5): 696.
  • The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat
  • Hwang JW, Lee MJ, Chung TN, Lee HA, Lee HJ, Choi SY, Park YJ, Kim CH, Jin I, Kim SH, Kwak HB, Heo JW, Na K, Choi S, Choi YS*, Kim K*., Crit. Care, 2021, 25:20.
  • ABL001, a Bispecific Antibody Targeting VEGF and DLL4, with Chemotherapy, Synergistically Inhibits Tumor Progression in Xenograft Models
  • Yeom DH, Lee YS, Ryu IH, Lee SJ, Sung BG, Lee HB, Kim DG, Ahn JH, Ha ES, Choi YS, Lee SH, You WK., Int. J. Mol. Sci., 2020, 22(1), 241.
  • CRH receptor antagonists from Pulsatilla chinensis prevent CRH-induced premature catagen transition in human hair follicles
  • Nam YJ, Lee, EY, Choi EJ, Kang S, Kim J, Choi YS, Kim DH, An JH, Han I, Lee S, Lee MH, Kim YH, Chung JH., J. Cosmetic Dermatol., 2020, 19(11): 3058-3066.
  • Umbilical cord mesenchymal stem cell-conditioned medium improves insulin resistance in C2C12 cell
  • Kim KS, Choi YK, Kim MJ, Hwang JW, Min K, Jung SY, Kim SK, Choi YS*, Cho YW. Diabetes Metab. J., 2020, Accepted. (IF 3.263)
  • CRH receptor antagonists from Pulsatilla chinensis prevent CRH-induced premature catagen transition in human hair follicles
  • Nam YJ, Lee, EY, Choi EJ, Kang S, Kim J, Choi YS, Kim DH, An JH, Han I, Lee S, Lee MH, Kim YH, Chung JH. J Cosmetic Dermatol, 2020, (DOI: 10.1111/jocd.13328). (IF 1.311)
  • Hair growth-promoting effect of recombinant human sonic hedgehog proteins
  • Yu SH, K Y, Jung N, Hwang JW, Kim N, Ha JC, Kim MJ, Lee Y, Choi YS, Han K, Kim CH. Biomed Dermatol, 2019, 3: 7.
  • The restoration of cellular proliferation and characteristics of human tenocytes by vitamin D
  • Min KH, Lee JM, Kim MJ, Jung SY, Kim KS, Lee SC, Choi YS*. J. Orthop. Res., 2019, 37(10). (IF 3.414)
  • Nanoinjection system for precise direct delivery of biomolecules into single cells (Featured Cover Article)
  • Yun CK, Hwang JW, Kwak TJ, Chang WJ, Ha SJ, Han KB, Lee SH, Choi YS*. Lab Chip, 2019, 19:580-588. (IF 6.914)
  • Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function
  • Kim MJ, Hwang JW, Yun CK, Lee YJ, Choi YS*. Sci. Rep., 2018, 8:3330. (IF 4.259)
  • Efficient cryopreservation of human mesenchymal stem cells using silkworm hemolymph-derived proteins
  • Kim SM, Yun CK, Park JH, Hwang JW, Kim ZH, Choi YS*. J Tissue Eng Regen Med., 2017, 11:8;2181–2192. (IF 5.199)
  • The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable response
  • Han YM, Park JM, Choi YS, Jin H, Lee YS, Han NY, Lee H, Hahm KB. Stem Cell Res Ther., 2017, 2;8(1). (IF 4.211)
  • Evaluation of the wound-healing activity of rice cell extracts in vitro
  • Kim ZH, Kim SM, Park JH, Park CM, Choi HY, Lee H, Park JK, Kwon S, Kim DI, Chang KH, Choi YS*, Lim SM. Microbiol Biotechnol Lett., 2016, 44(3).
  • Conditioned medium derived from umbilical cord mesenchymal stem cells regenerates atrophied muscles (Featured Cover Article)
  • Kim MJ, Kim ZH, Kim SM, Choi YS*. Tissue Cell., 2016, 48(5):533-43. (IF 1.258)
  • Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice
  • Byun SH, Lee JH, Jung NC, Choi HJ, Song JY, Han H, Choi J, Jung SY, Kang S, Choi YS, Chung JH, Lim DS. Biochem Pharmacol., 2016, 115: 85-93.. (IF 5.01)
  • Effects of storage-protein 2 derived from silkworm hemolymph on reduction of aggregation and cell death in CHO cells
  • Lim JH, Cha HM, Kim Z, Choi YS, Kim DI. Korean J Biotechnol Bioeng., 2016, 31(1): 66-72.
  • Umbilical cord mesenchymal stem cell-conditioned media prevent muscle atrophy by suppressing muscle atrophy-related proteins and ROS generation
  • Park CM, Kim MJ, Kim SM, Park JH, Kim ZH, Choi YS*. In Vitro Cell Dev Biol Anim., 2015, 52(1):68-76. (IF 1.145)
  • Scaffold-free Three-dimensional culture systems for mass production of periosteum-derived progenitor cells
  • Cha HM, Kim SM, Choi YS, Kim DI. J Biosci Bioeng., 2015, 120(2), 218-222. (IF 1.869)
  • A Composite Dermal Filler Comprising Cross-Linked Hyaluronic Acid and Human Collagen for Tissue Reconstruction
  • Kim ZH, Lee YJ, Kim SM, Kim HJ, Yun CK, and Choi YS*. J Microbiol Biotechnol., 2015, 25(3), 399–406. (IF 1.32)
  • Serum-free Media supplement from Silkworm gland for the expansion of mesenchymal stem cells
  • Cha HM, Kim SM, Choi YS*, Par JS, Lim JH, Hwang SG, Kim DI. Tissue Eng Regen Med., 2015, 12(s1): 53-59. (IF 0.613)
  • Sensitive and selective analysis of a wide concentration range ofIGFBP7 using a surface plasmon resonance biosensor
  • Jang DH, Choi YB, Choi YS, Kim SM, Kwak HJ, Shin SH, Hong SR. Colloids and Surfaces B: Biointerfaces., 2014, 123:887-891. (IF 4.287)
  • Short-term effects of etythropoietin on neurodevelopment in infants with cerebral palsy: A pilot study
  • Lee HS, Song J, Min K, Choi YS, Kim SM, Cho SR, Kim MY. Brain Dev., 2014, 36(9): 764-769. (IF 1.668)
  • Whitening effect of storage protein 2 from silkworm hemolymph
  • Kim ZH, Hwang JW, Lee JH, Kim H, Lim DS, Kang S, Lee HS, Choi YS*. Adv Biosci Biotechnol., 2014, 5: 758-767.
  • Transplantation of Insulin-Producing Cells Differentiated from Human Periosteum-Derived Progenitor Cells Ameliorate Hyperglycemia in Diabetic Mice
  • Dao LTM, Park EY, Lim SM, Choi YS, Jun HS. Transplantation., 2014, 98: 1040-1047. (IF 3.781)
  • Wound healing properties of a 3-D scaffold comprising soluble silkworm gland hydrolysate and human collagen
  • Kim KO, Lee Y, Hwang JW, Kim H, Lee HS, Choi YS*. Colloids Surf. B: Biointerfaces., 2014, 116: 318-326. (IF 4.287)
  • Pancreatic islet-like clusters from periosteum-derived progenitor cells
  • Kim SJ, Choi YS*. Kim SM, Lim SM, Park EY, Hwang OK, Jun HS, Lee CW, Kim DI. Biotechnol Bioprocess Eng., 2013, 18(6): 1116-1121. (IF 1.277)
  • Alternative xeno-free biomaterials derived from human umbilical cord for the self-renewal ex-vivo expansion of mesenchymal stem cells
  • Kim SM, Moon SH, Lee Y, Kim GJ, Chung HM, Choi YS*. Stem Cells Dev., 2013, 22(22): 3025-3038. (IF 4.67)
  • Development of a xeno-free autologous culture system for endothelial progenitor cells derived from human umbilical cord blood
  • Moon SH, Kim SM, Park SJ, Kim H, Bae D, Choi YS*, Chung HM. PLos One., 2013, 8(9): 1-10. (IF 3.73)
  • Whitening and anti-aging activities of soluble silkworm gland hydrolysate
  • Jung JH, Hwang JW, Kim H, Cha HM, Kim DI, Choi YS*. Korean J Biotechnol Bioeng., 2013, 28(3): 196-201.
  • Effects of Silkworm Gland Hydrolysate on Albumin-erythropoietin Production in Transgenic Chinese Hamster Ovary Cells
  • Choi MH, Cha HM, Kim SM, Choi YS, Kim DI. Korean J Biotechnol Bioeng., 2013, 28(2): 86-91.
  • Anti-oxidant and anti-aging activities of Sericinjam gland hydrolysate extract in human dermal fibroblasts
  • Cheon Y, Hwang JW, Lee HS, Yun S, Choi YS, Kang S. J Soc Cosmet., 2013, 39(1): 9-17.
  • Manufacture and characterization of silkworm gland hydrolysate
  • Hwang JW, Lee HS, Kim HJ, Kim KO, Choi YS*. J Seric Entomol Sci., 2012, 50(2): 76-81.
  • Human Placenta Extract Could Promote Proliferating Cell Nuclear Antigen Expression during Liver Regeneration Induced by Partial Hepatectomy in Rats
  • Kim JH, Han K, Choi YS, Lee YJ, Yoon KH, Han MD, Kim WJ. Applied Microscopy., 2012, 42(3): 115-123.
  • Glucose-stimulated insulin secretion of various mesenchymal stem cells after insulin-producing cell differentiation
  • Kim SJ, Choi YS, Ko ES, Lim SM, Lee CW, Kim DI. J Biosci Bioeng., 2012, 113(6): 771-777. (IF 1.737)
  • Effects of mixed feeder cells on the expansion of CD34+ cells
  • Choi YS, Lim DS, Lim SM, Kim DI. J Biosci Bioeng., 2012, 113(3): 389-394. (IF 1.737)
  • Mesenchymal stem cell-mediated immature dendritic cells induce regulatory T cell-based immunosuppressive effect
  • Choi YS, Jeong JA, Lim DS. Immunol Invest., 2012, 41: 214-229. (IF 1.731)
  • Optimization of ex vivo hematopoietic stem cell expansion in intermittent dynamic cultures
  • Choi YS, Noh SE, Lim SM, Kim DI. Biotechnol Lett., 2010, 32: 1969-1975. (IF 1.853)

저서/역서/편서

    [특허]
  • 분리된 미토콘드리아를 유효성분으로 포함하는 아셔만 증후군 예방 도는 치료용 약학 조성물
  • 분리된 미토콘드리아 보존용 조성물, 이를 포함하는 약학적 조성물 및 하이드로겔(기술이전)
  • 누에 혈림프 유래 저분자를 포함하는 모발 보호 및 수복용 화장용 조성물
  • 분리된 미토콘드리아를 유효성분으로 포함하는 패혈증 또는 전신성 염증 반응 증후군 치료용 약학 조성물(기술이전)
  • 분리된 미토콘드리아를 유효성분으로 포함하는 당뇨병 치료제(기술이전)
  • 분리된 미토콘드리아를 포함하는 건병증 예방 또는 치료용 약학 조성물(기술이전)
  • 미토콘드리아를 포함하는 허혈성 질환 예방 또는 치료용 조성물(기술이전)
  • 미토콘드리아를 포함하는 근질환 예장 또는 치료용 약학 조성물(기술이전)
  • 개질된 미토콘드리아 및 이의 용도
  • 분리된 미토콘드리아를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물(기술이전)
  • 외래 미토콘드리아를 세포로 전달하는 방법(기술이전)
  • 세포 배양용 지지체, 이의 제조 방법 및 이를 이용한 세포 배양 방법(기술이전)
  • 미토콘드리아를 포함하는 약학 조성물(기술이전)
  • 분리된 미토콘드리아를 유효성문으로 포함하는 탈모 예방 및 발모 촉진용 약학 조성물
  • 지방흡입 유출물로부터 초임계공정을 이용하여 콜라겐을 분리하는 방법
  • 미토콘드리아를 포함하는 허혈성 질환 예방 또는 치료용 조성물(기술이전)
  • 포유류 탯줄 유래 줄기세포 배양액을 유효성분으로 포함하는 근위축증의 예방 또는 치료용 약제학적 조성물
  • 누에 혈림프 유래 70KDa 단백질을 포함하는 화장료 조성물(기술이전)
  • 누에 혈림프 유래 단백질 및 그의 용도
  • 인간 제대혈 유래 내피 전구세포의 배양방법 및 인간 제대혈 유래 내피 전구세포를 포함하는 허혈성 질환의 예방 또는 치료용 조성물
  • 탯줄 유래 줄기세포를 포함하는 근위축 질환 개선 또는 치료용 조성물
  • 누에실샘 유래 가수분해물을 포함하는 화장료 조성물
  • 콜라겐 및 히알루론산 유도체를 포함하는 의료용 복합 생체 소재(기술이전)
  • 콜라겐, 히알루론산 유도체 및 포유류의 탯줄 유래 줄기세포를 포함하는 연골세포치료제(기술이전)
  • 탯줄 추출물의 제조방법 및 그의 용도(기술이전)
  • 누에 실샘 유래 가수분해물을 이용한 의료용 드레싱재 및 그 제조방밥
  • 누에 실샘 유래 가수분해물의 수득방법
  • 누에 혈림프 유래 단백질의 대량 정제방법 및 이를 통해 정제된 단백질
  • 누에 실샘 초미세분말 유래 수용성 세리신을 포함하는 화장료 조성물
  • 포유류의 탯줄 유래 줄기세포 분리 또는 배양용 배지 조성물, 그리고 이를 이용한 포유류의 탯줄 유래 줄기세포 분리 또는 배양방법(기술이전)